Matches in UGent Biblio for { <https://biblio.ugent.be/publication/537104#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B183540.
- aggregation creator B183541.
- aggregation creator person.
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- aggregation date "2009".
- aggregation format "application/pdf".
- aggregation hasFormat 537104.bibtex.
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- aggregation hasFormat 537104.doc.
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- aggregation isPartOf urn:issn:0264-410X.
- aggregation language "eng".
- aggregation publisher "Elsevier".
- aggregation rights "I don't know the status of the copyright for this publication".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Spray-dried powders of starch and crosslinked poly(acrylic acid) as carriers for nasal delivery of inactivated influenza vaccine".
- aggregation abstract "mucosal vaccination has several advantages over parenteral vaccination. In this study,viscosity-enhancing mucosal delivery systems for the induction of an adaptive immune response against viral antigen were investigated. Powder formulations based on spray-dried mixtures of starch (Amioca (R))/poly(acrylic acid) (Carbopol (R) 974P) in different ratios were used as carriers of the viral antigen. A comparison of these formulations for intranasal delivery of heat-inactivated influenza virus combined with LTR 192G adjuvant was made in vivo in a rabbit model. Individual rabbit sera were tested for seroconversion against hemagglutinin (HA), the major surface antigen of influenza. The powder vaccine formulations were able to induce systemic anti-HA IgG responses. The presence of Carbopol (R) 974P improved the kinetics of the immune responses and the level of IgG titers in a dose-dependent way which was correlated with moderately irritating capacities of the formulation. In contrast, mucosal IgA responses were not detected. In conclusion, it was demonstrated that the use of bioadhesive carriers based on Amioca (R) starch and poly(acrylic acid) facilitates the induction of a systemic anti-HA antibody response after intranasal vaccination with a whole virus influenza vaccine.".
- aggregation authorList BK439790.
- aggregation endPage "1286".
- aggregation issue "8".
- aggregation startPage "1279".
- aggregation volume "27".
- aggregation aggregates 2936554.
- aggregation isDescribedBy 537104.
- aggregation similarTo j.vaccine.2008.12.013.
- aggregation similarTo LU-537104.