Matches in UGent Biblio for { <https://biblio.ugent.be/publication/537409#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B171282.
- aggregation creator B171283.
- aggregation creator B171284.
- aggregation creator B171285.
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- aggregation date "2009".
- aggregation format "application/pdf".
- aggregation hasFormat 537409.bibtex.
- aggregation hasFormat 537409.csv.
- aggregation hasFormat 537409.dc.
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- aggregation isPartOf urn:issn:1535-9476.
- aggregation language "eng".
- aggregation publisher "AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC".
- aggregation subject "Chemistry".
- aggregation title "Analysis of Protein Processing by N-terminal Proteomics Reveals Novel Species-specific Substrate Determinants of Granzyme B Orthologs".
- aggregation abstract "Using a targeted peptide-centric proteomics approach, we performed in vitro protease substrate profiling of the apoptotic serine protease granzyme B resulting in the delineation of more than 800 cleavage sites in 322 human and 282 mouse substrates, encompassing the known substrates Bid, caspase-7, lupus La protein, and fibrillarin. Triple SILAC (stable isotope labeling by amino acids in cell culture) further permitted intra-experimental evaluation of species-specific variations in substrate selection by the mouse or human granzyme B ortholog. For the first time granzyme B substrate specificities were directly mapped on a proteomic scale and revealed unknown cleavage specificities, uncharacterized extended specificity profiles, and macromolecular determinants in substrate selection that were confirmed by molecular modeling. We further tackled a substrate hunt in an in vivo setup of natural killer cell-mediated cell death confirming in vitro characterized granzyme B cleavages next to several other unique and hitherto unreported proteolytic events in target cells.".
- aggregation authorList BK421321.
- aggregation endPage "272".
- aggregation issue "2".
- aggregation startPage "258".
- aggregation volume "8".
- aggregation aggregates 3112801.
- aggregation isDescribedBy 537409.
- aggregation similarTo mcp.M800060-MCP200.
- aggregation similarTo LU-537409.