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- aggregation classification "C3".
- aggregation creator person.
- aggregation creator person.
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- aggregation date "2014".
- aggregation format "application/pdf".
- aggregation hasFormat 5486709.bibtex.
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- aggregation language "eng".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Mechanisms involved in resveratrol-induced relaxation of isolated mice corpora cavernosa".
- aggregation abstract "Introduction: Red wine consumption has been linked to cardiovascular benefits. This is partly due to the presence of the wine compounds resveratrol (Resv) and quercetin (Quer). These are natural occurring polyphenols with known vasorelaxant capacity. Vasodilators often have a potential to regulate penile erection and could therefore be beneficial for the treatment of erectile dysfunction (ED). Aims: The goal of this study was to determine the relaxant effect of the polyphenols Resv and Quer on mice corpora cavernosa (CC)and the mechanisms involved. Methods: Isometric tension measurements on isolated mice CC were performed in organ baths. Cumulative concentration-response curves (10–100 μM) were constructed for Resv and Quer. Main outcome measures: Relaxation responses of CC to Resv and Quer in the presence/absence of inhibitors of different molecular pathways were measured. Results: Despite the fact that both polyphenols are potent vasodilators of mice aorta, only Resv relaxes mice CC. The relaxant effect of Resv on CC was significantly diminished by pretreatment with SQ 22,536, an adenylyl cyclase (AC) inhibitor and 8-Bromoadenosine-3′,5′-cyclic monophosphorothioate, Rp-isomer, a protein kinase A inhibitor. Also compound C, a 5’ adenosine monophosphate-activated protein kinase (AMPK) inhibitor significantly decreased the relaxant effect of Resv on CC. Conclusion: The red wine compound Resv, but not Quer, relaxes mice CC in vitro through activation of AC, leading to increased cAMP levels as well as through AMPK activation. Whether Resv could be beneficial for patients suffering from ED remains uncertain and requires further research.".
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