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- aggregation classification "A1".
- aggregation creator B819368.
- aggregation creator B819369.
- aggregation creator B819370.
- aggregation creator B819371.
- aggregation creator person.
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- aggregation creator person.
- aggregation date "2013".
- aggregation format "application/pdf".
- aggregation hasFormat 5638319.bibtex.
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- aggregation hasFormat 5638319.dc.
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- aggregation isPartOf urn:issn:0315-162X.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Nailfold capillaroscopy for prediction of novel future severe organ involvement in systemic sclerosis".
- aggregation abstract "Objective. Assessment of associations of nailfold videocapillaroscopy (NVC) scleroderma (systemic sclerosis; SSc) ("early," "active," and "late") with novel future severe clinical involvement in 2 independent cohorts. Methods. Sixty-six consecutive Belgian and 82 Italian patients with SSc underwent NYC at baseline. Images were blindly assessed and classified into normal, early, active, or late NYC pattern. Clinical evaluation was performed for 9 organ systems (general, peripheral vascular, skin, joint, muscle, gastrointestinal tract, lung, heart, and kidney) according to the Medsger disease severity scale (DSS) at baseline and in the future (18-24 months of followup). Severe clinical involvement was defined as category 2 to 4 per organ of the DSS. Logistic regression analysis (continuous NYC predictor variable) was performed. Results. The OR to develop novel future severe organ involvement was stronger according to more severe NVC patterns and similar in both cohorts. In simple logistic regression analysis the OR in the Belgian/Italian cohort was 2.16 (95% CI 1.19-4.47, p = 0.010)/2.33 (95% CI 1.36-4.22, p = 0.002) for the early NYC SSc pattern, 4.68/5.42 for the active pattern, and 10.14/12.63 for the late pattern versus the normal pattern. In multiple logistic regression analysis, adjusting for disease duration, subset, and vasoactive medication, the OR was 2.99 (95% CI 1.31-8.82, p = 0.007)/1.88 (95% CI 1.00-3.71, p = 0.050) for the early NYC SSc pattern, 8.93/3.54 for the active pattern, and 26.69/6.66 for the late pattern versus the normal pattern. Conclusion. Capillaroscopy may be predictive of novel future severe organ involvement in SSc, as attested by 2 independent cohorts.".
- aggregation authorList BK1192490.
- aggregation endPage "2028".
- aggregation issue "12".
- aggregation startPage "2023".
- aggregation volume "40".
- aggregation aggregates 5638362.
- aggregation isDescribedBy 5638319.
- aggregation similarTo jrheum.130528.
- aggregation similarTo LU-5638319.