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- aggregation classification "A1".
- aggregation creator person.
- aggregation date "2014".
- aggregation format "application/pdf".
- aggregation hasFormat 5644002.bibtex.
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- aggregation hasFormat 5644002.dc.
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- aggregation hasFormat 5644002.doc.
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- aggregation isPartOf urn:issn:1751-5521.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Antiphospholipid antibody testing and standardization".
- aggregation abstract "The laboratory criteria that define patients with antiphospholipid syndrome (APS) include lupus anticoagulant (LAC), anticardiolipin antibodies and anti-beta 2 glycoprotein I antibodies (a beta 2GPI). All assays show methodological shortcomings and the combination of the three tests, each with different sensitivity and specificity, and hence, differences in clinical utility make the laboratory diagnosis of APS challenging. Consensus guidelines and proposals for antiphospholipid antibodies (aPL) testing have been published in the last 20years and have led to a substantial improvement. Despite efforts so far, standardization is not reached yet, but progress has been made. On-going efforts to reduce the interlaboratory/interassay variations remain important; even an absolute standardization cannot be feasibly achieved. Taking into account the methodological shortcomings of the means we have available, more detailed guidelines may help in adequate performance of aPL testing. This review will focus on the efforts and achievements in standardization and on the weaknesses and strengths of the current available laboratory methods.".
- aggregation authorList BK1445236.
- aggregation endPage "363".
- aggregation issue "3".
- aggregation startPage "352".
- aggregation volume "36".
- aggregation aggregates 5644731.
- aggregation isDescribedBy 5644002.
- aggregation similarTo ijlh.12234.
- aggregation similarTo LU-5644002.