Matches in UGent Biblio for { <https://biblio.ugent.be/publication/5647137#aggregation> ?p ?o. }
Showing items 1 to 34 of
34
with 100 items per page.
- aggregation classification "A1".
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2014".
- aggregation format "application/pdf".
- aggregation hasFormat 5647137.bibtex.
- aggregation hasFormat 5647137.csv.
- aggregation hasFormat 5647137.dc.
- aggregation hasFormat 5647137.didl.
- aggregation hasFormat 5647137.doc.
- aggregation hasFormat 5647137.json.
- aggregation hasFormat 5647137.mets.
- aggregation hasFormat 5647137.mods.
- aggregation hasFormat 5647137.rdf.
- aggregation hasFormat 5647137.ris.
- aggregation hasFormat 5647137.txt.
- aggregation hasFormat 5647137.xls.
- aggregation hasFormat 5647137.yaml.
- aggregation isPartOf urn:issn:1559-2294.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "The H3K27me3 demethylase UTX in normal development and disease".
- aggregation abstract "In 2007, the Ubiquitously Transcribed Tetratricopeptide Repeat on chromosome X (UTX) was identified as a histone demethylase that specifically targets di- and tri-methyl groups on lysine 27 of histone H3 (H3K27me2/3). Since then, UTX has been proven essential during normal development, as it is critically required for correct reprogramming, embryonic development and tissue-specific differentiation. UTX is a member of the MLL2 H3K4 methyltransferase complex and its catalytic activity has been linked to regulation of HOX and RB transcriptional networks. In addition, an H3K27me2/3 demethylase independent function for UTX was uncovered in promoting general chromatin remodeling in concert with the BRG1-containing SWI/SNF remodeling complex. Constitutional inactivation of UTX causes a specific hereditary disorder called the Kabuki syndrome, whereas somatic loss of UTX has been reported in a variety of human cancers. Here, we compile the breakthrough discoveries made from the first disclosure of UTX as a histone demethylase till the identification of disease-related UTX mutations and specific UTX inhibitors.".
- aggregation authorList BK1368091.
- aggregation endPage "668".
- aggregation issue "5".
- aggregation startPage "658".
- aggregation volume "9".
- aggregation aggregates 5647143.
- aggregation isDescribedBy 5647137.
- aggregation similarTo epi.28298.
- aggregation similarTo LU-5647137.