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- aggregation classification "A1".
- aggregation creator B1022631.
- aggregation creator B1022632.
- aggregation creator B1022633.
- aggregation creator B1022634.
- aggregation creator B1022635.
- aggregation creator B1022636.
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- aggregation creator B1022638.
- aggregation creator person.
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- aggregation date "2014".
- aggregation format "application/pdf".
- aggregation hasFormat 5658604.bibtex.
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- aggregation isPartOf urn:issn:1545-7885.
- aggregation language "eng".
- aggregation rights "I have retained and own the full copyright for this publication".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "A20-Deficient mast cells exacerbate inflammatory responses in vivo".
- aggregation abstract "Mast cells are implicated in the pathogenesis of inflammatory and autoimmune diseases. However, this notion based on studies in mast cell-deficient mice is controversial. We therefore established an in vivo model for hyperactive mast cells by specifically ablating the NF-kappa B negative feedback regulator A20. While A20 deficiency did not affect mast cell degranulation, it resulted in amplified pro-inflammatory responses downstream of IgE/Fc epsilon RI, TLRs, IL-1R, and IL-33R. As a consequence house dust mite- and IL-33-driven lung inflammation, late phase cutaneous anaphylaxis, and collagen-induced arthritis were aggravated, in contrast to experimental autoimmune encephalomyelitis and immediate anaphylaxis. Our results provide in vivo evidence that hyperactive mast cells can exacerbate inflammatory disorders and define diseases that might benefit from therapeutic intervention with mast cell function.".
- aggregation authorList BK1437181.
- aggregation issue "1".
- aggregation volume "12".
- aggregation aggregates 5658659.
- aggregation isDescribedBy 5658604.
- aggregation similarTo journal.pbio.1001762.
- aggregation similarTo LU-5658604.