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- aggregation classification "A1".
- aggregation creator B982552.
- aggregation creator B982553.
- aggregation creator B982554.
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- aggregation creator person.
- aggregation creator person.
- aggregation date "2012".
- aggregation format "application/pdf".
- aggregation hasFormat 5707445.bibtex.
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- aggregation isPartOf urn:issn:0002-9440.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Recent developments in myofibroblast biology paradigms for connective tissue remodeling".
- aggregation abstract "The discovery of the myofibroblast has opened new perspectives for the comprehension of the biological mechanisms involved in wound healing and fibrotic diseases. In recent years, many advances have been made in understanding important aspects of myofibroblast basic biological characteristics. This review summarizes such advances in several fields, such as the following: i) force production by the myofibroblast and mechanisms of connective tissue remodeling; factors controlling the expression of alpha-smooth muscle actin, the most used marker of myofibroblastic phenotype and, more important, involved in force generation by the myofibroblast; and factors affecting genesis of the myofibroblast and its differentiation from precursor cells, in particular epigenetic factors, such as DNA methylation, microRNAs, and histone modification. We also review the origin and the specific features of the myofibroblast in diverse fibrotic lesions, such as systemic sclerosis; kidney, liver, and lung fibrosis; and the stromal reaction to certain epithelial tumors. Finally, we summarize the emerging Strategies for influencing myofibroblast behavior in vitro and in vivo, with the ultimate goal of an effective therapeutic approach for myofibroblast-dependent diseases.".
- aggregation authorList BK1381791.
- aggregation endPage "1355".
- aggregation issue "4".
- aggregation startPage "1340".
- aggregation volume "180".
- aggregation aggregates 5707476.
- aggregation isDescribedBy 5707445.
- aggregation similarTo j.ajpath.2012.02.004.
- aggregation similarTo LU-5707445.