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- aggregation classification "A1".
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2014".
- aggregation hasFormat 5707492.bibtex.
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- aggregation hasFormat 5707492.yaml.
- aggregation isPartOf urn:issn:0363-6135.
- aggregation language "eng".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Small size ionic heterogeneities in the human heart can attract rotors".
- aggregation abstract "Rotors occurring in the heart underlie the mechanisms of cardiac arrhythmias. Answering the question whether or not the location of rotors is related to local properties of cardiac tissue has important practical applications. This is because ablation of rotors has been shown to be an effective way to fight cardiac arrhythmias. In this study, we investigate, in silico, the dynamics of rotors in 2D and in an anatomical model of human ventricles using a TNNP model for ventricular cells. We study the effect of small size ionic heterogeneities, similar to those measured experimentally. It is shown that such heterogeneities can not only anchor, but can also attract rotors rotating at a substantial distance from the heterogeneity. This attraction distance depends on the extent of the heterogeneities and can be as large as 5-6 cm in realistic conditions. We conclude that small size ionic heterogeneities can be preferred localization points for rotors, and discuss their possible mechanism and value for applications.".
- aggregation authorList BK1320124.
- aggregation isDescribedBy 5707492.
- aggregation similarTo ajpheart.00410.2014.
- aggregation similarTo LU-5707492.