Matches in UGent Biblio for { <https://biblio.ugent.be/publication/5737548#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B983133.
- aggregation creator B983134.
- aggregation creator person.
- aggregation creator person.
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- aggregation creator person.
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- aggregation date "2014".
- aggregation format "application/pdf".
- aggregation hasFormat 5737548.bibtex.
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- aggregation hasFormat 5737548.didl.
- aggregation hasFormat 5737548.doc.
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- aggregation isPartOf urn:issn:1613-4125.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "O⁶-carboxymethylguanine DNA adduct formation and lipid peroxidation upon in vitro gastrointestinal digestion of haem-rich meat".
- aggregation abstract "Scope: Epidemiological and clinical studies have demonstrated that the consumption of red haem-rich meat may contribute to the risk of colorectal cancer. Two hypotheses have been put forward to explain this causal relationship, i.e. N-nitroso compound (NOC) formation and lipid peroxidation (LPO). Methods and Results: In this study, the NOC-derived DNA adduct O-6-carboxymethylguanine (O-6-CMG) and the LPO product malondialdehyde (MDA) were measured in individual in vitro gastrointestinal digestions of meat types varying in haem content (beef, pork, chicken). While MDA formation peaked during the in vitro small intestinal digestion, alkylation and concomitant DNA adduct formation was observed in seven (out of 15) individual colonic digestions using separate faecal inocula. From those, two haem-rich meat digestions demonstrated a significantly higher O-6-CMG formation (p < 0.05). MDA concentrations proved to be positively correlated (p < 0.0004) with haem content of digested meat. The addition of myoglobin, a haem-containing protein, to the digestive simulation showed a dose-response association with O-6-CMG (p = 0.004) and MDA (p = 0.008) formation. Conclusion: The results suggest the haem-iron involvement for both the LPO and NOC pathway during meat digestion. Moreover, results unambiguously demonstrate that DNA adduct formation is very prone to inter-individual variation, suggesting a person-dependent susceptibility to colorectal cancer development following haem-rich meat consumption.".
- aggregation authorList BK1383145.
- aggregation endPage "1896".
- aggregation issue "9".
- aggregation startPage "1883".
- aggregation volume "58".
- aggregation aggregates 5737565.
- aggregation isDescribedBy 5737548.
- aggregation similarTo mnfr.201400078.
- aggregation similarTo LU-5737548.