Matches in UGent Biblio for { <https://biblio.ugent.be/publication/595603#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B190236.
- aggregation creator B190237.
- aggregation creator B190238.
- aggregation creator B190239.
- aggregation creator B190240.
- aggregation creator B190241.
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- aggregation creator B190249.
- aggregation creator person.
- aggregation date "2009".
- aggregation format "application/pdf".
- aggregation hasFormat 595603.bibtex.
- aggregation hasFormat 595603.csv.
- aggregation hasFormat 595603.dc.
- aggregation hasFormat 595603.didl.
- aggregation hasFormat 595603.doc.
- aggregation hasFormat 595603.json.
- aggregation hasFormat 595603.mets.
- aggregation hasFormat 595603.mods.
- aggregation hasFormat 595603.rdf.
- aggregation hasFormat 595603.ris.
- aggregation hasFormat 595603.txt.
- aggregation hasFormat 595603.xls.
- aggregation hasFormat 595603.yaml.
- aggregation isPartOf urn:issn:0925-4773.
- aggregation language "eng".
- aggregation title "Requirement of Wnt/beta-catenin signaling in pronephric kidney development".
- aggregation abstract "The pronephric kidney controls water and electrolyte balance during early fish and amphibian embryogenesis. Many Wnt signaling components have been implicated in kidney development. Specifically, in Xenopus pronephric development as well as the murine metanephroi, the secreted glycoprotein Wnt-4 has been shown to be essential for renal tubule formation. Despite the importance of Wnt signals in kidney organogenesis, little is known of the definitive downstream signaling pathway(s) that mediate their effects. Here we report that inhibition of Wnt/beta-catenin signaling within the pronephric field of Xenopus results in significant losses to kidney epithelial tubulogenesis with little or no effect on adjoining axis or somite development. We find that the requirement for Wnt/beta-catenin signaling extends throughout the pronephric primordium and is essential for the development of proximal and distal tubules of the pronephros as well as for the development of the duct and glomus. Although less pronounced than effects upon later pronephric tubule differentiation, inhibition of the Wnt/beta-catenin pathway decreased expression of early pronephric mesenchymal markers indicating it is also needed in early pronephric patterning. We find that upstream inhibition of Wnt/beta-catenin signals in zebrafish likewise reduces pronephric epithelial tubulogenesis. We also find that exogenous activation of Wnt/beta-catenin signaling within the Xenopus pronephric field results in significant tubulogenic losses. Together, we propose Wnt/beta-catenin signaling is required for pronephric tubule, duct and glomus formation in Xenopus laevis, and this requirement is conserved in zebrafish pronephric tubule formation.".
- aggregation authorList BK448649.
- aggregation endPage "159".
- aggregation issue "3-4".
- aggregation startPage "142".
- aggregation volume "126".
- aggregation aggregates 2936642.
- aggregation isDescribedBy 595603.
- aggregation similarTo j.mod.2008.11.007.
- aggregation similarTo LU-595603.