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- aggregation classification "A1".
- aggregation creator B257479.
- aggregation creator B257480.
- aggregation creator B257481.
- aggregation creator B257482.
- aggregation creator B257483.
- aggregation creator B257484.
- aggregation creator B257485.
- aggregation creator B257486.
- aggregation creator B257487.
- aggregation creator person.
- aggregation date "2008".
- aggregation hasFormat 603964.bibtex.
- aggregation hasFormat 603964.csv.
- aggregation hasFormat 603964.dc.
- aggregation hasFormat 603964.didl.
- aggregation hasFormat 603964.doc.
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- aggregation hasFormat 603964.yaml.
- aggregation isPartOf urn:issn:1567-2026.
- aggregation language "eng".
- aggregation publisher "BENTHAM SCIENCE PUBL LTD".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "A SELDI-TOF-MS study in lacunar stroke with subsequent haptoglobin phenotyping".
- aggregation abstract "Using Surface-Enhanced Laser Desorption / Ionization Time-of-Flight Mass Spectrometry (SELDI-TOF-MS), we aimed to detect differences in protein profile in serum samples of two lacunar stroke subtypes. SELDI-TOF-MS, followed by protein identification, was performed in samples of 8 first-ever lacunar stroke patients with MR imaging showing a single symptomatic lacunar lesion (type 1), and 8 with multiple additional "silent" lacunar lesions and extensive white matter lesions type 2). A 16 kDa protein, identified as alpha-2-chain of haptoglobin (Hp), was found to be overrepresented in type 1 compared to type 2 (peak intensity 12.5 vs. 5.0; p=0.02). As a polymorphism with two alleles, Hp-1 and Hp-2, determines the presence of alpha-1 and/or alpha-2-chains in the Hp-molecule, Hp phenotypic analysis was performed. Hp-1 : Hp-2 allele frequency was 0.562 : 0.438 in type 1 and 0.812 : 0.188 in type 2 (population reference similar to 0.4 : 0.6). We conclude that the overrepresentation of the alpha-2-chain in lacunar stroke type 1 compared to type 2 relates to a higher Hp-2 allele frequency in the former. Yet, compared to population reference, the phenotype distribution in both patient groups deviates towards a high Hp-1 allele frequency. Our findings suggest a role for the Hp gene in the etiology of cerebral small vessel disease. Larger studies are now needed to explore this new candidate gene.".
- aggregation authorList BK533271.
- aggregation endPage "98".
- aggregation issue "2".
- aggregation startPage "93".
- aggregation volume "5".
- aggregation isDescribedBy 603964.
- aggregation similarTo LU-603964.