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- aggregation classification "A1".
- aggregation creator person.
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- aggregation date "2009".
- aggregation format "application/pdf".
- aggregation hasFormat 684956.bibtex.
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- aggregation isPartOf urn:issn:1352-0504.
- aggregation language "eng".
- aggregation title "The HCV serum proteome: a search for fibrosis protein markers".
- aggregation abstract "Liver fibrosis/cirrhosis is a serious health issue in hepatitis C virus (HCV-) infected patients and is currently diagnosed by the invasive liver biopsy. The aim of this study was to find useful fibrosis markers in HCV-patients' sera of different fibrosis degrees (METAVIR F0-F4) based on proteomics. Serum proteome profiles were created by two-dimensional gel electrophoresis. Profiles were analysed between different degrees of fibrosis (F0-F4) and between early (F0F1) and late (F2F3F4) fibrosis by univariate analyses (P <= 0.05). Differentially expressed proteins were subsequently identified by mass spectrometry. Mac-2-binding protein, alpha-2-macroglobulin and hemopexin were increased in F4 opposite F0/F1. A-1-antitrypsin, leucine-rich alpha-2-glycoprotein and fetuin-A were decreased in F4 opposite F0/F1. Late fibrosis was characterized by an increase in Mac-2-binding protein, alpha-2-macroglobulin and alpha-1B-glycoprotein expression and a decrease in haptoglobin expression. Mac-2-binding protein expression was confirmed by dot blot assay and enzyme-linked immunosorbent assay in a secondary population. In conclusion, serum proteome analysis enabled the detection/identification of existing and new candidate markers in line with fibrosis progression in HCV-patients.".
- aggregation authorList BK565909.
- aggregation endPage "429".
- aggregation issue "6".
- aggregation startPage "418".
- aggregation volume "16".
- aggregation aggregates 702398.
- aggregation isDescribedBy 684956.
- aggregation similarTo j.1365-2893.2009.01083.x.
- aggregation similarTo LU-684956.