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- aggregation classification "A1".
- aggregation creator B292960.
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- aggregation creator person.
- aggregation date "1996".
- aggregation hasFormat 714970.bibtex.
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- aggregation isPartOf urn:issn:0028-0836.
- aggregation language "eng".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene".
- aggregation abstract "HIV-1 and related viruses require co-receptors, in addition to CD4, to infect target cells. The chemokine receptor CCR-5 (ref. 1) was recently demonstrated to be a co-receptor for macrophage-tropic (M-tropic) HIV-1 strains(2-6), and the orphan(7) receptor LESTR (also called fusin) allows infection by strains adapted for growth in transformed T-cell lines (T-tropic strains). Here we show that a mutant allele of CCR-5 is present at a high frequency in caucasian populations (allele frequency, 0.092), but is absent in 'black populations from Western and Central Africa and Japanese populations. A 32-base-pair deletion within the coding region results in a frame shift, and generates a non-functional receptor that does not support membrane fusion or infection by macrophage- and dual-tropic HIV-1 strains. In a cohort of HIV-1-infected caucasian subjects, no individual homozygous for the mutation was found, and the frequency of heterozygotes was 35% lower than in the general population. White blood cells from an individual homozygous for the null allele were found to be highly resistant to infection by M-tropic HIV-1 viruses, confirming that CCR-5 is the major cc-receptor for primary HIV-1 strains, The lower frequency of heterozygotes in seropositive patients may indicate partial resistance.".
- aggregation authorList BK578150.
- aggregation endPage "725".
- aggregation issue "6593".
- aggregation startPage "722".
- aggregation volume "382".
- aggregation isDescribedBy 714970.
- aggregation similarTo 382722a0.
- aggregation similarTo LU-714970.