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- aggregation classification "A1".
- aggregation creator B437661.
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- aggregation date "2008".
- aggregation format "application/pdf".
- aggregation hasFormat 744632.bibtex.
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- aggregation isPartOf urn:issn:0006-4971.
- aggregation language "eng".
- aggregation title "Subcutaneous panniculitis-like T-cell lymphoma: definition, classification, and prognostic factors: an EORTC Cutaneous Lymphoma Group Study of 83 cases".
- aggregation abstract "In the WHO classification, subcutaneous panniculitis-like T-cell lymphoma (SPTL) is defined as a distinct type of T-cell lymphoma with an aggressive clinical behavior. Recent studies suggest that distinction should be made between SPTL with an (alpha/beta T-cell phenotype (SPTL-AB) and SPTL with a gamma delta T-cell phenotype (SPTL-GD), but studies are limited. To better define their clinicopathologic features, immunophenotype, treatment, and survival, 63 SPTL-ABs and 20 SPTL-GDs were studied at a workshop of the EORTC Cutaneous Lymphoma Group. SPTL-ABs were generally confined to the subcutis, had a CD4(-), CD8(+), CD56(-), beta F1(+) phenotype, were uncommonly associated with a hemophagocytic syndrome (HPS; 17%), and had a favorable prognosis (5-year overall survival [OS]: 82%). SPTL-AB patients without HPS had a significantly better survival than patients with HIPS (5-year OS: 91% vs 46%; P < .001). SPTL-GDs often showed (epi)dermal involvement and/or ulceration, a CD4(-), CD8(-), CD56(+/-), beta F1(-) T-cell phenotype, and poor prognosis (5-year OS: 11%), irrespective of the presence of HPS or type of treatment. These results indicate that SPTL-AB and SPTL-GD are distinct entities, and justify that the term SPTL should further be used only for SPTL-AB. SPTL-ABs without associated HPS have an excellent prognosis, and multiagent chemotherapy as first choice of treatment should be questioned.".
- aggregation authorList BK763534.
- aggregation endPage "845".
- aggregation issue "2".
- aggregation startPage "838".
- aggregation volume "111".
- aggregation aggregates 769075.
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- aggregation similarTo blood-2007-04-087288.
- aggregation similarTo LU-744632.