Matches in UGent Biblio for { <https://biblio.ugent.be/publication/748632#aggregation> ?p ?o. }
Showing items 1 to 37 of
37
with 100 items per page.
- aggregation classification "A1".
- aggregation creator B417722.
- aggregation creator B417723.
- aggregation creator B417724.
- aggregation creator B417725.
- aggregation creator B417726.
- aggregation creator B417727.
- aggregation creator B417728.
- aggregation creator B417729.
- aggregation creator person.
- aggregation date "2009".
- aggregation hasFormat 748632.bibtex.
- aggregation hasFormat 748632.csv.
- aggregation hasFormat 748632.dc.
- aggregation hasFormat 748632.didl.
- aggregation hasFormat 748632.doc.
- aggregation hasFormat 748632.json.
- aggregation hasFormat 748632.mets.
- aggregation hasFormat 748632.mods.
- aggregation hasFormat 748632.rdf.
- aggregation hasFormat 748632.ris.
- aggregation hasFormat 748632.txt.
- aggregation hasFormat 748632.xls.
- aggregation hasFormat 748632.yaml.
- aggregation isPartOf urn:issn:1567-2026.
- aggregation language "eng".
- aggregation publisher "BENTHAM SCIENCE PUBL LTD, EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Haptoglobin Phenotype May Alter Endothelial Progenitor Cell Cluster Formation in Cerebral Small Vessel Disease".
- aggregation abstract "Cerebral small vessel disease results in silent ischemic lesions (SIL) among which is leukoaraiosis. In this process, endothelial damage is probably involved. Endothelial progenitor cells (EPC), are involved in endothelial repair. By restoring the damaged endothelium, EPC could mitigate SIL and cerebral small vessel disease. Haptoglobin 1-1, one of three phenotypes of haptoglobin, relates to SIL and may therefore attenuate the endothelial repair by EPC. Our aim was to quantify EPC number and function and to assess haptoglobin phenotype and its effect on EPC function in patients with a high prevalence of SIL: lacunar stroke patients. We assessed EPC In 42 lacunar stroke patients and 18 controls by flow cytometry and culture with fetal calf serum, patient and control serum. We determined haptoglobin phenotype and cultured EPC with the three different haptoglobin phenotypes. We found that EPC cluster counts were lower in patients (96.9 clusters/ well +/- 83.4 (mean +/- SD)), especially in those with SIL (85.0 +/- 64.3), than in controls (174.4 +/- 112.2). Cluster formation was inhibited by patient serum, especially by SIL patient serum, but not by control serum. Patients with haptoglobin 1-1 had less clusters in culture, and when haptoglobin 1-1 was added to EPC cultures, cluster numbers were lower than with the other haptoglobin phenotypes. We conclude that lacunar stroke patients, especially those with SIL, have impaired EPC cluster formation, which may point at decreased endothelial repair potential. The haptoglobin 1-1 phenotype is likely a causative factor in this impairment.".
- aggregation authorList BK738174.
- aggregation endPage "41".
- aggregation issue "1".
- aggregation startPage "32".
- aggregation volume "6".
- aggregation isDescribedBy 748632.
- aggregation similarTo LU-748632.