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- aggregation classification "A1".
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2009".
- aggregation format "application/pdf".
- aggregation hasFormat 748928.bibtex.
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- aggregation isPartOf urn:issn:0173-0835.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Analysis of γ-globulin mobility on routine clinical CE equipment: exploring its molecular basis and potential clinical utility".
- aggregation abstract "A study was conducted on the variability of gamma-globulin mobility in serum protein electrophoresis and its molecular basis. We found that the migration time of gamma-globulins can be reproducibly determined (CV = 1.1%) on clinical CE equipment. Moreover, we found a significant difference (p<0.001) in the migration of gamma-globulins between chronic liver disease patients (n = 98) and a healthy reference group (n = 47). Serum immunoglobulins were purified from these patients' sera using protein L-agarose and their glycosylation was studied using CE on a DNA sequencer. This glycomics approach revealed that several non-sialylated N-glycans show a moderate Pearson correlation coefficient (r = 0.2-0.4) with the migration time of gamma-globulins. Their sialylated structures correlate negatively (r = -0.2 to -0.3). Immunoglobulins are significantly more sialylated in the healthy reference group compared with the patients (p<0.001). We estimated that sialylation heterogeneity contributes about 36% to the molecular variance (carbohydrates and amino-acid composition) that affects the electrophoretic mobility of immunoglobulins. This is the first report on the migration time of gamma-globulins on a clinical CE instrument and its potential clinical value to the routinely analyzed serum protein CE profiles.".
- aggregation authorList BK738185.
- aggregation endPage "2623".
- aggregation issue "15".
- aggregation startPage "2617".
- aggregation volume "30".
- aggregation aggregates 2936788.
- aggregation isDescribedBy 748928.
- aggregation similarTo elps.200900054.
- aggregation similarTo LU-748928.