Matches in UGent Biblio for { <https://biblio.ugent.be/publication/770709#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B381958.
- aggregation creator B381959.
- aggregation creator B381960.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
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- aggregation creator person.
- aggregation creator person.
- aggregation date "2009".
- aggregation format "application/pdf".
- aggregation hasFormat 770709.bibtex.
- aggregation hasFormat 770709.csv.
- aggregation hasFormat 770709.dc.
- aggregation hasFormat 770709.didl.
- aggregation hasFormat 770709.doc.
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- aggregation hasFormat 770709.yaml.
- aggregation isPartOf urn:issn:0039-128X.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Detection and structural investigation of metabolites of stanozolol in human urine by liquid chromatography tandem mass spectrometry".
- aggregation abstract "The applicability of LC-MS/MS in precursor ion scan mode for the detection of urinary stanozolol metabolites has been studied. The product ion at m/z 81 has been selected as specific for stanozolol metabolites without a modification in A- or N-rings and the product ions at m/z 97 and 145 for the metabolites hydroxylated in the N-ring and 4-hydroxy-stanozolol metabolites, respectively. Under these conditions, the parent drug and up to 15 metabolites were found in a positive doping test sample. The study of a sample from a chimeric uPA-SCID mouse collected after the administration of stanozolol revealed the presence of 4 additional metabolites. The information obtained from the product ion spectra was used to develop a SRM method for the detection of 19 compounds. This SRM method was applied to several doping positive samples. All the metabolites were detected in both the uPA-SCID mouse sample and positive human samples and were not detected in none of the blank samples tested; confirming the metabolic nature of all the detected compounds. In addition, the application of the SRM method to a single human excretion study revealed that one of the metabolites (4 xi,16 xi-dihydroxy-stanozolol) could be detected in negative ionization mode for a longer period than those commonly used in the screening for stanozolol misuse (3'-hydroxy-stanozolol, 16 beta-hydroxy-stanozolol and 4 beta-hydroxy-stanozolol) in doping analysis. The application of the developed approach to several positive doping samples confirmed the usefulness of this metabolite for the screening of stanozolol misuse. Finally, a tentative structure for each detected metabolite has been proposed based on the product ion spectra measured with accurate masses using UPLC-QTOF MS. (C) 2009 Elsevier Inc. All rights reserved.".
- aggregation authorList BK690092.
- aggregation endPage "852".
- aggregation issue "10-11".
- aggregation startPage "837".
- aggregation volume "74".
- aggregation aggregates 778078.
- aggregation isDescribedBy 770709.
- aggregation similarTo j.steroids.2009.05.004.
- aggregation similarTo LU-770709.