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- aggregation classification "A1".
- aggregation creator B224144.
- aggregation creator B224145.
- aggregation creator B224146.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2010".
- aggregation format "application/pdf".
- aggregation hasFormat 798903.bibtex.
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- aggregation hasFormat 798903.doc.
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- aggregation isPartOf urn:issn:0022-3565.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Metabolic fate of lactoferricin based antimicrobial peptides: effect of truncation and incorporation of amino acid analogs on the in vitro metabolic stability".
- aggregation abstract "A series of promising truncated antibacterial tripeptides derived from lactoferricin has been prepared, and their in vitro metabolic stability in the main metabolic compartments, plasma, liver, kidney, stomach, duodenum, and brain, has been investigated for the first time. The potential stabilizing effect of truncation, C-terminal capping, and introduction of the bulky synthetic amino acid biphenylalanine is also investigated. The drug-like peptides displayed large differences in half-lives in the different matrixes ranging from 4.2 min in stomach and duodenum to 355.9 min in liver. Kinetic analysis of the metabolites revealed that several different degrading enzymes simultaneously target the different peptide bonds and that the out-come of the tested strategies to increase the stability is clearly enzyme-specific. Some of the metabolic enzymes even prefer the synthetic modifications incorporated over the natural counterparts. Collectively, it is shown that the necessary antibacterial pharmacophore generates compounds that are not only potent antibacterial peptides, but excellent substrates for the main degrading enzymes. All the amide bonds are thus rapidly targeted by different enzymes despite the short peptidic sequences of the tested compounds. Hence, our results illustrate that several structural changes are needed before these compounds can be considered for oral administration. Strategies to overcome such metabolic challenges are discussed.".
- aggregation authorList BK490947.
- aggregation endPage "1039".
- aggregation issue "3".
- aggregation startPage "1032".
- aggregation volume "332".
- aggregation aggregates 3047813.
- aggregation aggregates 806313.
- aggregation isDescribedBy 798903.
- aggregation similarTo jpet.109.162826.
- aggregation similarTo LU-798903.