Matches in UGent Biblio for { <https://biblio.ugent.be/publication/833586#aggregation> ?p ?o. }
Showing items 1 to 38 of
38
with 100 items per page.
- aggregation classification "A1".
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2009".
- aggregation format "application/pdf".
- aggregation hasFormat 833586.bibtex.
- aggregation hasFormat 833586.csv.
- aggregation hasFormat 833586.dc.
- aggregation hasFormat 833586.didl.
- aggregation hasFormat 833586.doc.
- aggregation hasFormat 833586.json.
- aggregation hasFormat 833586.mets.
- aggregation hasFormat 833586.mods.
- aggregation hasFormat 833586.rdf.
- aggregation hasFormat 833586.ris.
- aggregation hasFormat 833586.txt.
- aggregation hasFormat 833586.xls.
- aggregation hasFormat 833586.yaml.
- aggregation isPartOf urn:issn:1756-994X.
- aggregation language "eng".
- aggregation rights "I have retained and own the full copyright for this publication".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "The emerging molecular pathogenesis of neuroblastoma: implications for improved risk assessment and targeted therapy".
- aggregation abstract "Neuroblastoma is one of the most common solid tumors of childhood, arising from immature sympathetic nervous system cells. The clinical course of patients with neuroblastoma is highly variable, ranging from spontaneous regression to widespread metastatic disease. Although the outcome for children with cancer has improved considerably during the past decades, the prognosis of children with aggressive neuroblastoma remains dismal. The clinical heterogeneity of neuroblastoma mirrors the biological and genetic heterogeneity of these tumors. Ploidy and MYCN amplification have been used as genetic markers for risk stratification and therapeutic decision making, and, more recently, gene expression profiling and genome-wide DNA copy number analysis have come into the picture as sensitive and specific tools for assessing prognosis. The applica tion of new genetic tools also led to the discovery of an important familial neuroblastoma cancer gene, ALK, which is mutated in approximately 8% of sporadic tumors, and genome-wide association studies have unveiled loci with risk alleles for neuroblastoma development. For some of the genomic regions that are deleted in some neuroblastomas, on 1p, 3p and 11q, candidate tumor suppressor genes have been identified. In addition, evidence has emerged for the contribution of epigenetic disturbances in neuroblastoma oncogenesis. As in other cancer entities, altered microRNA expression is also being recognized as an important player in neuroblastoma. The recent successes in unraveling the genetic basis of neuroblastoma are now opening opportunities for development of targeted therapies.".
- aggregation authorList BK693202.
- aggregation issue "7".
- aggregation volume "1".
- aggregation aggregates 837438.
- aggregation isDescribedBy 833586.
- aggregation similarTo gm74.
- aggregation similarTo LU-833586.