Matches in UGent Biblio for { <https://biblio.ugent.be/publication/833904#aggregation> ?p ?o. }
Showing items 1 to 34 of
34
with 100 items per page.
- aggregation classification "A1".
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2009".
- aggregation format "application/pdf".
- aggregation hasFormat 833904.bibtex.
- aggregation hasFormat 833904.csv.
- aggregation hasFormat 833904.dc.
- aggregation hasFormat 833904.didl.
- aggregation hasFormat 833904.doc.
- aggregation hasFormat 833904.json.
- aggregation hasFormat 833904.mets.
- aggregation hasFormat 833904.mods.
- aggregation hasFormat 833904.rdf.
- aggregation hasFormat 833904.ris.
- aggregation hasFormat 833904.txt.
- aggregation hasFormat 833904.xls.
- aggregation hasFormat 833904.yaml.
- aggregation isPartOf urn:issn:0959-9673.
- aggregation language "eng".
- aggregation publisher "WILEY-BLACKWELL PUBLISHING, INC".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Experimental mouse models for hepatocellular carcinoma research".
- aggregation abstract "Every year almost 500,000 new patients are diagnosed with hepatocellular carcinoma (HCC), a primary malignancy of the liver that is associated with a poor prognosis. Numerous experimental models have been developed to define the pathogenesis of HCC and to test novel drug candidates. This review analyses several mouse models useful for HCC research and points out their advantages and weaknesses. Chemically induced HCC mice models mimic the injury-fibrosis-malignancy cycle by administration of a genotoxic compound alone or, if necessary, followed by a promoting agent. Xenograft models develop HCC by implanting hepatoma cell lines in mice, either ectopically or orthotopically; these models are suitable for drug screening, although extrapolation should be considered with caution as multiple cell lines must always be used. The hollow fibre assay offers a solution for limiting the number of test animals in xenograft research because of the ability for implanting multiple cell lines in one mouse. There is also a broad range of genetically modified mice engineered to investigate the pathophysiology of HCC. Transgenic mice expressing viral genes, oncogenes and/or growth factors allow the identification of pathways involved in hepatocarcinogenesis.".
- aggregation authorList BK693223.
- aggregation endPage "386".
- aggregation issue "4".
- aggregation startPage "367".
- aggregation volume "90".
- aggregation aggregates 838600.
- aggregation isDescribedBy 833904.
- aggregation similarTo j.1365-2613.2009.00656.x.
- aggregation similarTo LU-833904.