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- aggregation classification "A1".
- aggregation creator B441681.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2009".
- aggregation format "application/pdf".
- aggregation hasFormat 835273.bibtex.
- aggregation hasFormat 835273.csv.
- aggregation hasFormat 835273.dc.
- aggregation hasFormat 835273.didl.
- aggregation hasFormat 835273.doc.
- aggregation hasFormat 835273.json.
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- aggregation hasFormat 835273.txt.
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- aggregation hasFormat 835273.yaml.
- aggregation isPartOf urn:issn:0002-9637.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Influence of Tropical Climate Conditions on the Quality of Antihypertensive Drugs from Rwandan Pharmacies".
- aggregation abstract "The objective of this study was to assess the quality of antihypertensive drugs and to investigate the influence of tropical storage conditions. Drug content and in vitro dissolution tests were performed on 10 test formulations (from Rwanda) and 6 reference formulations (from Belgium or France) after purchase and after 6-month storage under long-term (25 +/- 2 degrees C and 60 +/- 5% relative humidity [RH]) and accelerated (40 +/- 2 degrees C and 75 +/- 5% RH) testing conditions. Twenty percent of test formulations were of substandard content at the time of purchase. After 6 months at accelerated testing conditions, 7 of 10 test formulations were substandard in content and 8 were substandard for the combined criteria of drug content and dissolution, whereas no reference drug became substandard. This study shows that, apart from some drugs being already substandard from purchase, accelerated testing conditions (simulating tropical climate) have deleterious effects on the majority of antihypertensive drug formulations found in the Rwandan market.".
- aggregation authorList BK770757.
- aggregation endPage "781".
- aggregation issue "5".
- aggregation startPage "776".
- aggregation volume "81".
- aggregation aggregates 1096786.
- aggregation isDescribedBy 835273.
- aggregation similarTo ajtmh.2009.09-0109.
- aggregation similarTo LU-835273.