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- aggregation classification "A1".
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2010".
- aggregation format "application/pdf".
- aggregation hasFormat 842803.bibtex.
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- aggregation isPartOf urn:issn:0955-3002.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Dose response and repair kinetics of γ-H2AX foci induced by in vitro irradiation of whole blood and T-lymphocytes with X- and γ-radiation".
- aggregation abstract "Purpose: Dose response and repair kinetics of γ-H2AX foci in T-lymphocytes were investigated in the low dose range after in vitro irradiation of whole blood and T-lymphocytes with 100kVp X-rays and 60Co γ-rays. Materials and methods: Whole blood or isolated T-lymphocytes were irradiated in vitro and γ-H2AX foci were scored. Dose response was determined in the 0–500mGy dose range. Foci kinetics were studied at doses of 5mGy and 200mGy up to 24h post-irradiation. Results: After X-irradiation, the dose response for whole blood shows a biphasic behaviour with a low dose hypersensitivity, which is less pronounced for isolated T-lymphocytes. In contrast, γ-radiation shows a linear dose response for both irradiation conditions. Concerning repair kinetics, delayed repair was found after X-ray whole blood irradiation (5mGy and 200mGy) with 40% of the foci persisting 24h post-irradiation. This number of foci is reduced to 10% after irradiation of isolated T-lymphocytes with 200mGy X-rays. On the contrary, γ-H2AX foci are reduced to background levels 24h post-irradiation with 200mGy 60Co γ-rays. Conclusions: γ-H2AX foci response and repair kinetics depend on irradiation conditions and radiation quality, possibly linked to bystander response.".
- aggregation authorList BK716153.
- aggregation endPage "768".
- aggregation issue "9".
- aggregation startPage "760".
- aggregation volume "86".
- aggregation aggregates 1045146.
- aggregation isDescribedBy 842803.
- aggregation similarTo 09553002.2010.484479.
- aggregation similarTo LU-842803.