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- aggregation classification "A1".
- aggregation creator B384605.
- aggregation creator B384606.
- aggregation creator B384607.
- aggregation creator B384608.
- aggregation creator B384609.
- aggregation creator B384610.
- aggregation creator B384611.
- aggregation creator B384612.
- aggregation creator B384613.
- aggregation creator B384614.
- aggregation creator person.
- aggregation date "2003".
- aggregation format "application/pdf".
- aggregation hasFormat 847246.bibtex.
- aggregation hasFormat 847246.csv.
- aggregation hasFormat 847246.dc.
- aggregation hasFormat 847246.didl.
- aggregation hasFormat 847246.doc.
- aggregation hasFormat 847246.json.
- aggregation hasFormat 847246.mets.
- aggregation hasFormat 847246.mods.
- aggregation hasFormat 847246.rdf.
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- aggregation hasFormat 847246.txt.
- aggregation hasFormat 847246.xls.
- aggregation hasFormat 847246.yaml.
- aggregation isPartOf urn:issn:0016-5085.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Hypoglycemia, defective islet glucagon secretion, but normal islet mass in mice with a disruption of the gastrin gene".
- aggregation abstract "Background&Aims: Both cholecystokinin (CCK)-A and CCK-B receptors are expressed in the pancreas, and exogenous gastrin administration stimulates glucagon secretion from human islets. Although gastrin action has been linked to islet neogenesis, transdifferentiation, and beta-cell regeneration, an essential physiologic role(s) for gastrin in the pancreas has not been established. Methods: We examined glucose homeostasis, glucagon gene expression, glucagon secretion, and islet mass in mice with a targeted gastrin gene disruption. Results: Gastrin -/- mice exhibit fasting hypoglycemia and significantly reduced glycemic excursion following glucose challenge. Insulin sensitivity was normal and levels of circulating insulin and insulin messenger RNA transcripts were appropriately reduced in gastrin -/- mice. In contrast, levels of circulating glucagon and pancreatic glucagon messenger RNA transcripts were not up-regulated in hypoglycemic gastrin -/- mice. Furthermore, the glucagon response to epinephrine in isolated perifused islets was moderately impaired in gastrin -/- versus gastrin +/+ islets (40% reduction; P < 0.01, gastrin +/+ vs. gastrin -/- mice). Moreover, the glucagon response but not the epinephrine response to hypoglycemia was significantly attenuated in gastrin -/- compared with gastrin +/+ mice (P < 0.05). Despite gastrin expression in the developing fetal pancreas, beta-cell area, islet topography, and the islet proliferative response to experimental injury were normal in gastrin -/- mice. Conclusions: These findings show an essential physiologic role for gastrin in glucose homeostasis; however, the gastrin gene is not essential for murine islet development or the adaptive islet proliferative response to beta-cell injury.".
- aggregation authorList BK695360.
- aggregation endPage "1174".
- aggregation issue "4".
- aggregation startPage "1164".
- aggregation volume "125".
- aggregation aggregates 855418.
- aggregation isDescribedBy 847246.
- aggregation similarTo S0016-5085(03)01195-8.
- aggregation similarTo LU-847246.