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- aggregation classification "A1".
- aggregation creator B329740.
- aggregation creator B329741.
- aggregation creator B329742.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2009".
- aggregation hasFormat 849652.bibtex.
- aggregation hasFormat 849652.csv.
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- aggregation hasFormat 849652.didl.
- aggregation hasFormat 849652.doc.
- aggregation hasFormat 849652.json.
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- aggregation hasFormat 849652.xls.
- aggregation hasFormat 849652.yaml.
- aggregation isPartOf urn:issn:0022-2623.
- aggregation language "eng".
- aggregation subject "Chemistry".
- aggregation title "Synthesis of novel 2-alkoxy-3-amino-3-arylpropan-1-ols and 5-alkoxy-4-aryl-1,3-oxazinanes with antimalarial activity".
- aggregation abstract "A variety of novel syn-2-alkoxy-3-amino-3-arylpropan-1-ols was prepared through LiAlH4-promoted reductive ring-opening of cis-3-alkoxy-4-aryl-beta-lactams in Et2O. The latter gamma-aminoalcohols were easily converted into cis-5-alkoxy-4-aryl-1,3-oxazinanes using formaldehyde in THE Both series of compounds were evaluated against a chloroquine sensitive strain of Plasmodium falciparum (D10), revealing micromolar potency for almost all representatives. Eleven compounds exhibited antimalarial activity with IC50 values of <= 30 mu M, and the majority of these compounds did not show cytotoxicity at the concentrations tested.".
- aggregation authorList BK621961.
- aggregation endPage "4062".
- aggregation issue "13".
- aggregation startPage "4058".
- aggregation volume "52".
- aggregation isDescribedBy 849652.
- aggregation similarTo jm9002632.
- aggregation similarTo LU-849652.