Matches in UGent Biblio for { <https://biblio.ugent.be/publication/851426#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B440087.
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- aggregation date "2009".
- aggregation hasFormat 851426.bibtex.
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- aggregation hasFormat 851426.didl.
- aggregation hasFormat 851426.doc.
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- aggregation hasFormat 851426.txt.
- aggregation hasFormat 851426.xls.
- aggregation hasFormat 851426.yaml.
- aggregation isPartOf urn:issn:0250-7005.
- aggregation language "eng".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Xanthohumol activates the proapoptotic arm of the unfolded protein response in chronic lymphocytic leukemia".
- aggregation abstract "Background: Chronic lymphocytic leukemia (CLL) is an incurable disease with a natural history of increasing resistance to chemotherapy. A novel approach to overcome chemotherapy resistance may be targeting the endoplasmic reticulum (ER). Patients and Methods: The involvement of the unfolded protein response (UPR) in the cell killing effect of xanthohumol (X) was examined in 18 patient. samples. Results: X-induced apoptosis of CLL cells was accompanied by the induction of glucose-regulated protein of 78 kDa (GRP78) and heat-shock protein of 70 kDa (Hsp70) protein levels and by sustained phosphorylation of the eukaryotic translation initiation factor 2 (eIF2a), suggesting the involvement of the ER stress transducer, the double-stranded RNA-activated protein kinase (PKR)-like ER kinase (PERK). The X-box-binding protein 1 (XBP1) mRNA was spliced but no clear activation of activating transcription factor 6 (ATF6) was observed. The proapoptotic outcome was further demonstrated by the up-regulation of CCAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP), down-regulation of myeloid cell leukemia 1 (Mcl-1) and B-cell lymphoma 2 (Bcl-2), cleavage of poly-(ADP)-ribose polymerase (PARP) and processing of caspase-3, -4 and -9. Furthermore, X showed proteasome inhibitory activity. Conclusion: X stimulates the proapoptotic arm of the UPR in ex vivo CLL cells, suggesting that ER stress may play an important role during X-induced apoptosis.".
- aggregation authorList BK768041.
- aggregation endPage "3805".
- aggregation issue "10".
- aggregation startPage "3797".
- aggregation volume "29".
- aggregation isDescribedBy 851426.
- aggregation similarTo LU-851426.