Matches in Ghent University Academic Bibliography for { <https://biblio.ugent.be/publication/8533756> ?p ?o. }
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- 8533756 classification A1.
- 8533756 date "2017".
- 8533756 language "eng".
- 8533756 type journalArticle.
- 8533756 hasPart 8533757.pdf.
- 8533756 subject "Biology and Life Sciences".
- 8533756 subject "Medicine and Health Sciences".
- 8533756 doi "10.1038/s41598-017-06236-6".
- 8533756 issn "2045-2322".
- 8533756 volume "7".
- 8533756 abstract "Due to their capacity to skew T cell responses towards Th1 oriented immunity, oligonucleotides containing unmethylated CpG motifs (CpG) have emerged as interesting adjuvants for vaccination. Whereas the signalling pathways in response to CpG mediated TLR9 activation have been extensively documented at the level of the individual cell, little is however known on the precise identity of the innate immune cells that govern T cell priming and polarisation to CpG adjuvanted protein antigens in vivo. In this study, we demonstrate that optimal induction of Th1 oriented immunity to CpG adjuvanted protein vaccines requires the coordinated actions of conventional DCs and of monocytes. Whilst conventional DCs were required for antigen presentation and initial T cell priming, monocytes constitute the main source of the Th1 polarising cytokine IL-12.".
- 8533756 author 05CBBE6C-F0EE-11E1-A9DE-61C894A0A6B4.
- 8533756 author 1F1D02F4-F0EE-11E1-A9DE-61C894A0A6B4.
- 8533756 author F4331416-F0ED-11E1-A9DE-61C894A0A6B4.
- 8533756 author F48175CA-F0ED-11E1-A9DE-61C894A0A6B4.
- 8533756 author F6D12F14-F0ED-11E1-A9DE-61C894A0A6B4.
- 8533756 author F778B0A4-F0ED-11E1-A9DE-61C894A0A6B4.
- 8533756 author F8C23F66-F0ED-11E1-A9DE-61C894A0A6B4.
- 8533756 author F946B58E-F0ED-11E1-A9DE-61C894A0A6B4.
- 8533756 author F94C50D4-F0ED-11E1-A9DE-61C894A0A6B4.
- 8533756 author F97AEC46-F0ED-11E1-A9DE-61C894A0A6B4.
- 8533756 author F9A1D126-F0ED-11E1-A9DE-61C894A0A6B4.
- 8533756 author FA4B0890-F0ED-11E1-A9DE-61C894A0A6B4.
- 8533756 dateCreated "2017-10-10T14:45:43Z".
- 8533756 dateModified "2024-07-09T12:40:57Z".
- 8533756 name "Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12".
- 8533756 pagination urn:uuid:e249d32f-6289-4a4a-ba3d-51c7ea896772.
- 8533756 sameAs LU-8533756.
- 8533756 sourceOrganization urn:uuid:43eff3c9-351f-4010-8f5d-337b1b8df086.
- 8533756 sourceOrganization urn:uuid:5f1c9b9a-5b2a-45ec-b68a-2f53c34d29ce.
- 8533756 sourceOrganization urn:uuid:a17c231f-293f-4874-a4e5-cce1d729486a.
- 8533756 sourceOrganization urn:uuid:c555df06-962c-459e-a346-bc1cc3406e3b.
- 8533756 type A1.