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- 8551774 classification A1.
- 8551774 date "2017".
- 8551774 language "eng".
- 8551774 type journalArticle.
- 8551774 hasPart 8551775.pdf.
- 8551774 subject "Biology and Life Sciences".
- 8551774 doi "10.3920/BM2016.0013".
- 8551774 issn "1876-2883".
- 8551774 issn "1876-2891".
- 8551774 issue "1".
- 8551774 volume "8".
- 8551774 abstract "Host mucin is the main constituent of the mucus layer that covers the gut epithelium of the host, and an important source of glycans for the bacteria colonising the intestine. Akkermansia muciniphila is a mucin-degrading bacterium, abundant in the human gut, that is able to produce acetate and propionate during this degradation process. A. muciniphila has been correlated with human health in previous studies, but a mechanistic explanation is lacking. In this study, the main site of colonisation was characterised alongside additional conditions, such as differences in colon pH, prebiotic supplementation and variable mucin supply. To overcome the limitations of in vivo studies concerning variations in mucin availability and difficult access to proximal regions of the colon, a dynamic in vitro gut model (SHIME) was used. In this model, A. muciniphila was found to colonise the distal colon compartment more abundantly than the proximal colon ((+/- 8 log copies/ml compared to +/- 4 log copies/ml) and the preference for the distal compartment was found to be pH-dependent. The addition of mucin caused a specific increase of A. muciniphila (+/- 4.5 log increase over two days), far exceeding the response of other bacteria present, together with an increase in propionate. These findings suggest that colonisation and mucin degradation by A. muciniphila is dependent on pH and the concentration of mucin. Our results revealed the preference of A. muciniphila for the distal colon environment due to its higher pH and uncovered the quick and stable response of A. muciniphila to mucin supplementation.".
- 8551774 author 09CD5E80-F0EE-11E1-A9DE-61C894A0A6B4.
- 8551774 author 0F9542D8-F0EE-11E1-A9DE-61C894A0A6B4.
- 8551774 author 16011408-F0EE-11E1-A9DE-61C894A0A6B4.
- 8551774 author 5B9712DC-6CC3-11E2-9EA0-5E6B10BDE39D.
- 8551774 author E85BE31E-9B17-11E2-A004-2F9C10BDE39D.
- 8551774 author F5FDB080-F0ED-11E1-A9DE-61C894A0A6B4.
- 8551774 author F986D77C-F0ED-11E1-A9DE-61C894A0A6B4.
- 8551774 author FB5ECBAE-F0ED-11E1-A9DE-61C894A0A6B4.
- 8551774 author urn:uuid:01523fc0-783a-444a-bcf5-16dd24a75957.
- 8551774 author urn:uuid:07c85954-6f75-432c-98c0-91b8c5e9bfc6.
- 8551774 author urn:uuid:68ccf476-c3ac-42de-b298-85a527fa1d12.
- 8551774 author urn:uuid:8a5ddb4f-e8dc-414b-be63-3c0b32694255.
- 8551774 dateCreated "2018-02-23T15:12:07Z".
- 8551774 dateModified "2024-07-09T12:51:47Z".
- 8551774 name "In vitro colonisation of the distal colon by Akkermansia muciniphila is largely mucin and pH dependent".
- 8551774 pagination urn:uuid:5551a58d-1528-4afa-ab60-23b5643b7a98.
- 8551774 sameAs LU-8551774.
- 8551774 sourceOrganization urn:uuid:8e01b1bf-b243-4a16-a36b-74a57a40624a.
- 8551774 type A1.