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- aggregation classification "A1".
- aggregation creator person.
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- aggregation date "2010".
- aggregation format "application/pdf".
- aggregation hasFormat 859158.bibtex.
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- aggregation isPartOf urn:issn:1062-3264.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Morbidity and mortality of bloodstream infections in patients with severe burn injury".
- aggregation abstract "Objective: To evaluate the effects of bloodstream infections [BSI] in patients with severe burn injuries. Methods: Retrospective (1992-2006), pairwise-matched (ratio 1:1 to 1:2), risk-adjusted cohort study in a 6-bed burn unit. A comparison was made between ‘exposed’ patients with microbiologically documented BSI (n=76) and non-exposed subjects (n=103) matched on burn severity (identical Belgian Outcome in Burn Injury [BOBI] score) and length of hospitalization (equivalent or longer than the time-to-event in the exposed patient). Main outcome measures were length of hospitalization and mortality. Results: Predominant pathogens were Staphylococcus aureus, enterococci, Pseudomonas aeruginosa, Escherichia coli, coagulase-negative staphylococci, and Candida spp. Median age was 42 years (interquartile range [IQR] 31-52y). Median total burned surface area was 40% (IQR: 25-50%). Fifty-four percent experienced an inhalation injury. The median BOBI score was 4 (IQR: 2-5). The median ICU stay before onset of bacteremia was 11 days (IQR: 5.3-19.8d). Appropriate antimicrobial therapy was initiated within the first 48h in 76.3%. The exposed group had a higher need for vasopressive/inotropic support (57.9% vs. 39.8%, p=0.017), whereas need for ventilatory assistance and renal replacement therapy were not significantly higher. Hospital mortality did not differ (11.8% vs. 17.5%, p=0.298). However, BSI was associated with an additional length of hospitalization of 25 days (61 vs. 36d; p<0.001), and an excess length of mechanical ventilation of 11 days (21 vs. 10d; p<0.001). Conclusions: In this cohort of burn patients, BSI did not adversely affect survival, but contributes to a substantial economic burden through excess length of ventilator dependency and hospital stay.".
- aggregation authorList BK770913.
- aggregation endPage "e87".
- aggregation issue "6".
- aggregation startPage "e81".
- aggregation volume "19".
- aggregation aggregates 1074623.
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- aggregation similarTo ajcc2010341.
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