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- 8637424 classification A1.
- 8637424 date "2019".
- 8637424 language "eng".
- 8637424 type journalArticle.
- 8637424 hasPart 8637425.pdf.
- 8637424 subject "Biology and Life Sciences".
- 8637424 subject "Medicine and Health Sciences".
- 8637424 doi "10.3389/fphys.2019.01240".
- 8637424 issn "1664-042X".
- 8637424 volume "10".
- 8637424 abstract "Recently, it was suggested that beta-aminoisobutyric acid (BAIBA) is a myokine involved in browning of fat. However, there is no evidence for an acute effect of exercise supporting this statement and the metabolic distinct enantiomers of BAIBA were not taken into account. Concerning these enantiomers, there is at this point no consensus about resting concentrations of plasma R- and S-BAIBA. Additionally, a polymorphism of the alanine - glyoxylate aminotransferase 2 (AGXT2) gene (rs37369) is known to have a high impact on baseline levels of total BAIBA, but the effect on the enantiomers is unknown. Fifteen healthy recreationally active subjects, with different genotypes of rs37369, participated in a randomized crossover trial where they exercised for 1 h at 40% of P-peak or remained at rest. Plasma samples were analyzed for R- and S-BAIBA using dual column HPLC-fluorescence. The plasma concentration of baseline R-BAIBA was 67 times higher compared to S-BAIBA (1734 +/- 821 vs. 29.3 +/- 7.8 nM). Exercise induced a 13 and 20% increase in R-BAIBA and S-BAIBA, respectively. The AGXT2 rs37369 genotype strongly affected baseline levels of R-BAIBA, but did not have an impact on baseline S-BAIBA. We demonstrate that BAIBA should not be treated as one molecule, given (1) the markedly uneven distribution of its enantiomers in human plasma favoring R-BAIBA, and (2) their different metabolic source, as evidenced by the AGXT2 polymorphism only affecting R-BAIBA. The proposed function in organ cross talk is supported by the current data and may apply to both enantiomers, but the tissue of origin remains unclear.".
- 8637424 author 088CC63C-F0EE-11E1-A9DE-61C894A0A6B4.
- 8637424 author 1EB6F6BC-F0EE-11E1-A9DE-61C894A0A6B4.
- 8637424 author C21FC478-49B6-11E4-AA90-F166B5D1D7B1.
- 8637424 author F4EF24F8-F0ED-11E1-A9DE-61C894A0A6B4.
- 8637424 author FB7033E4-F0ED-11E1-A9DE-61C894A0A6B4.
- 8637424 author urn:uuid:3d116974-9881-498e-b2e7-7f90684f3a24.
- 8637424 author urn:uuid:e3a14840-b058-4059-a586-ccb5c120bcfe.
- 8637424 author urn:uuid:f51a662a-be33-4ab4-831f-486f18e8bad3.
- 8637424 dateCreated "2019-12-02T11:51:42Z".
- 8637424 dateModified "2024-07-09T13:35:10Z".
- 8637424 name "Acute aerobic exercise leads to increased plasma levels of R- and S-β-aminoisobutyric acid in humans".
- 8637424 pagination urn:uuid:6cb3769b-2f74-4079-b386-5a89d1c992c9.
- 8637424 sameAs LU-8637424.
- 8637424 sourceOrganization urn:uuid:d6a40ee3-ad4c-4499-b9c9-8a13222752c0.
- 8637424 type A1.