Matches in Ghent University Academic Bibliography for { <https://biblio.ugent.be/publication/8710728> ?p ?o. }
Showing items 1 to 31 of
31
with 100 items per page.
- 8710728 classification A1.
- 8710728 date "2021".
- 8710728 language "eng".
- 8710728 type journalArticle.
- 8710728 hasPart 8710833.pdf.
- 8710728 subject "Biology and Life Sciences".
- 8710728 subject "Chemistry".
- 8710728 subject "Medicine and Health Sciences".
- 8710728 doi "10.1186/s12943-021-01329-3".
- 8710728 issn "1476-4598".
- 8710728 issue "1".
- 8710728 volume "20".
- 8710728 abstract "mRNA therapeutics have become the focus of molecular medicine research. Various mRNA applications have reached major milestones at high speed in the immuno-oncology field. This can be attributed to the knowledge that mRNA is one of nature's core building blocks carrying important information and can be considered as a powerful vector for delivery of therapeutic proteins to the patient.For a long time, the major focus in the use of in vitro transcribed mRNA was on development of cancer vaccines, using mRNA encoding tumor antigens to modify dendritic cells ex vivo. However, the versatility of mRNA and its many advantages have paved the path beyond this application. In addition, due to smart design of both the structural properties of the mRNA molecule as well as pharmaceutical formulations that improve its in vivo stability and selective targeting, the therapeutic potential of mRNA can be considered as endless.As a consequence, many novel immunotherapeutic strategies focus on the use of mRNA beyond its use as the source of tumor antigens. This review aims to summarize the state-of-the-art on these applications and to provide a rationale for their clinical application.".
- 8710728 author 04E66146-F0EE-11E1-A9DE-61C894A0A6B4.
- 8710728 author 157F107A-F0EE-11E1-A9DE-61C894A0A6B4.
- 8710728 author 1F1D02F4-F0EE-11E1-A9DE-61C894A0A6B4.
- 8710728 author C3CF24E2-AA66-11E4-986E-18D2B4D1D7B1.
- 8710728 author F7247AC0-F0ED-11E1-A9DE-61C894A0A6B4.
- 8710728 author F94793D2-F0ED-11E1-A9DE-61C894A0A6B4.
- 8710728 author urn:uuid:94ba931c-97d5-4604-a4c4-b370afc93554.
- 8710728 dateCreated "2021-06-04T12:22:21Z".
- 8710728 dateModified "2024-07-09T14:06:21Z".
- 8710728 name "mRNA in cancer immunotherapy : beyond a source of antigen".
- 8710728 pagination urn:uuid:480a479a-cd8d-4a28-a3f5-b8b508ea83a0.
- 8710728 sameAs LU-8710728.
- 8710728 sourceOrganization urn:uuid:27493d05-07bc-417e-8b59-d94822207dfa.
- 8710728 sourceOrganization urn:uuid:2be34e46-8ab7-491f-b2b8-ba68127c6f38.
- 8710728 sourceOrganization urn:uuid:459b3878-0fc3-48af-b4bf-bdf290f428d2.
- 8710728 sourceOrganization urn:uuid:9c17e4e8-59f9-4e3a-991b-0b5acdbb1694.
- 8710728 sourceOrganization urn:uuid:f8872fa9-5820-4728-b03d-9f8f906f96e4.
- 8710728 type A1.