Matches in UGent Biblio for { <https://biblio.ugent.be/publication/874006#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
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- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2009".
- aggregation format "application/pdf".
- aggregation hasFormat 874006.bibtex.
- aggregation hasFormat 874006.csv.
- aggregation hasFormat 874006.dc.
- aggregation hasFormat 874006.didl.
- aggregation hasFormat 874006.doc.
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- aggregation isPartOf urn:issn:1613-4125.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Agriculture and Food Sciences".
- aggregation title "Hop bitter acids efficiently block inflammation independent of GRα, PPARα, or PPARγ".
- aggregation abstract "Hop (Humulus lupulus L.) is an essential ingredient of beer, where it provides the typical bitter taste, but is also applied in traditional folk medicine for sedative and antibacterial purposes. In this study, we demonstrate and compare the anti-inflammatory effect of various classes of hop bitter acids (HBA), including alpha-acids (AA), beta-acids (BA), and iso-alpha-acids (IAA), in fibroblasts, which are important players in the inflammatory response. All three studied classes of HBA blocked the turner necrosis factor alpha (TNF)-induced production of the cytokine IL6, and inhibited the transactivation of the pro-inflammatory transcription factors nuclear factor kappa B (NF-kappa B), activator protein-I (AP-1), and cAMP-response element-binding protein (CREB). In this respect, the six-membered ring compounds AA and BA showed equal potency, whereas the five-membered ring compounds, IAA, were effective only when used at higher concentrations. Furthermore, with regard to the mechanism of NF-kappa B suppression, we excluded a possible role for glucocorticoid receptor alpha (GR alpha), peroxisome proliferators-activated receptor alpha/gamma (PPAR alpha or PPAR gamma), nuclear receptors (NRs) that are also known to inhibit inflammation by directly interfering with the activity of pro-inflammatory transcription factors. Interestingly, combining hop acids and selective agonists for GR alpha, PPAR alpha, or PPAR gamma resulted in additive inhibition of NF-kappa B activity after TNF treatment, which may open up new avenues for combinatorial anti-inflammatory strategies with fewer side effects. Finally, systemic administration of HBA efficiently inhibited acute local inflammation in vivo.".
- aggregation authorList BK620788.
- aggregation endPage "1155".
- aggregation issue "9".
- aggregation startPage "1143".
- aggregation volume "53".
- aggregation aggregates 2937099.
- aggregation isDescribedBy 874006.
- aggregation similarTo mnfr.200800493.
- aggregation similarTo LU-874006.