Matches in UGent Biblio for { <https://biblio.ugent.be/publication/877387#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B331915.
- aggregation creator B331916.
- aggregation creator B331917.
- aggregation creator B331918.
- aggregation creator B331919.
- aggregation creator B331920.
- aggregation creator B331921.
- aggregation creator B331922.
- aggregation creator B331923.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2009".
- aggregation format "application/pdf".
- aggregation hasFormat 877387.bibtex.
- aggregation hasFormat 877387.csv.
- aggregation hasFormat 877387.dc.
- aggregation hasFormat 877387.didl.
- aggregation hasFormat 877387.doc.
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- aggregation hasFormat 877387.xls.
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- aggregation isPartOf urn:issn:1932-6203.
- aggregation language "eng".
- aggregation publisher "PUBLIC LIBRARY SCIENCE".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Pseudomonas aeruginosa Population Structure Revisited".
- aggregation abstract "At present there are strong indications that Pseudomonas aeruginosa exhibits an epidemic population structure; clinical isolates are indistinguishable from environmental isolates, and they do not exhibit a specific (disease) habitat selection. However, some important issues, such as the worldwide emergence of highly transmissible P. aeruginosa clones among cystic fibrosis (CF) patients and the spread and persistence of multidrug resistant (MDR) strains in hospital wards with high antibiotic pressure, remain contentious. To further investigate the population structure of P. aeruginosa, eight parameters were analyzed and combined for 328 unrelated isolates, collected over the last 125 years from 69 localities in 30 countries on five continents, from diverse clinical (human and animal) and environmental habitats. The analysed parameters were: i) O serotype, ii) Fluorescent Amplified-Fragment Length Polymorphism (FALFP) pattern, nucleotide sequences of outer membrane protein genes, iii) oprI, iv) oprL, v) oprD, vi) pyoverdine receptor gene profile (fpvA type and fpvB prevalence), and prevalence of vii) exoenzyme genes exoS and exoU and viii) group I pilin glycosyltransferase gene tfpO. These traits were combined and analysed using biological data analysis software and visualized in the form of a minimum spanning tree (MST). We revealed a network of relationships between all analyzed parameters and non-congruence between experiments. At the same time we observed several conserved clones, characterized by an almost identical data set. These observations confirm the nonclonal epidemic population structure of P. aeruginosa, a superficially clonal structure with frequent recombinations, in which occasionally highly successful epidemic clones arise. One of these clones is the renown and widespread MDR serotype O12 clone. On the other hand, we found no evidence for a widespread CF transmissible clone. All but one of the 43 analysed CF strains belonged to a ubiquitous P. aeruginosa "core lineage" and typically exhibited the exoS(+)/exoU(-) genotype and group B oprL and oprD alleles. This is to our knowledge the first report of an MST analysis conducted on a polyphasic data set.".
- aggregation authorList BK626278.
- aggregation issue "11".
- aggregation volume "4".
- aggregation aggregates 882300.
- aggregation isDescribedBy 877387.
- aggregation similarTo journal.pone.0007740.
- aggregation similarTo LU-877387.