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- aggregation classification "A1".
- aggregation creator B286086.
- aggregation creator B286087.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
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- aggregation date "2010".
- aggregation format "application/pdf".
- aggregation hasFormat 911311.bibtex.
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- aggregation hasFormat 911311.dc.
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- aggregation hasFormat 911311.yaml.
- aggregation isPartOf urn:issn:0032-5791.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Veterinary Sciences".
- aggregation title "Intestinal mucus protects Campylobacter jejuni in the ceca of colonized broiler chickens against the bactericidal effects of medium-chain fatty acids".
- aggregation abstract "Campylobacter jejuni is the most common cause of bacterial-mediated diarrhoeal disease worldwide. As poultry and poultry products are a major source of C. jejuni infections in humans, efforts should be taken to develop strategies to decrease Campylobacter shedding during primary production. For this purpose, the efficacy of medium-chain fatty acids (MCFA) as feed additives to control C. jejuni colonization in broiler chickens was analyzed. First, the antimicrobial activity of the MCFA caproic, caprylic, and capric acid on C. jejuni was evaluated in vitro. Minimal inhibitory concentrations (MIC) were 0.25 mM for caproic and 0.5 mM for caprylic and capric acid at pH 6.0, and 4 mM for all 3 compounds at pH 7.5. Time-kill curves revealed strong bactericidal properties of the tested compounds towards C. jejuni at pH 6.0. Concentrations as low as 4 mM of caprylic and capric acid, and 16 mM of caproic acid killed all bacteria within 24 h. Capric acid had the highest activity, with concentrations of 4 mM killing all bacteria within the hour. Together these data show a profound bactericidal, dose-dependent activity of the tested MCFA towards C. jejuni in vitro. For this reason, the effect of these 3 MCFA on C. jejuni was evaluated in vivo. The addition of any of the acids to the feed, from 3 d before euthanization, was not capable of reducing cecal Campylobacter colonization in 27-d-old broilers, experimentally infected with C. jejuni at 15 d of age. Using a ‘cecal loop’ model, sodium caprate was not able to reduce cecal Campylobacter counts. When time-kill curves were conducted in the presence of chick intestinal mucus, capric acid was less active against C. jejuni. At 4 mM, all bacteria were killed only after 24 h. Thus, despite the marked bactericidal effect of MCFA in vitro, supplementing these acids to the feed does not reduce cecal Campylobacter colonization in broiler chickens under the applied test conditions, probably due to the protective effect of the mucus layer.".
- aggregation authorList BK568062.
- aggregation endPage "1155".
- aggregation issue "6".
- aggregation startPage "1144".
- aggregation volume "89".
- aggregation aggregates 1041983.
- aggregation aggregates 935066.
- aggregation isDescribedBy 911311.
- aggregation similarTo ps.2010-00717.
- aggregation similarTo LU-911311.