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- aggregation classification "A1".
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- aggregation date "2010".
- aggregation format "application/pdf".
- aggregation hasFormat 931075.bibtex.
- aggregation hasFormat 931075.csv.
- aggregation hasFormat 931075.dc.
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- aggregation hasFormat 931075.doc.
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- aggregation isPartOf urn:issn:0092-8674.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease".
- aggregation abstract "Our findings that PlGF is a cancer target and anti-PlGF is useful for anticancer treatment have been challenged by Bais et al. Here we take advantage of carcinogen-induced and transgenic tumor models as well as ocular neovascularization to report further evidence in support of our original findings of PlGF as a promising target for anticancer therapies. We present evidence for the efficacy of additional anti-PlGF antibodies and their ability to phenocopy genetic deficiency or silencing of PlGF in cancer and ocular disease but also show that not all anti-PlGF antibodies are effective. We also provide additional evidence for the specificity of our anti-PlGF antibody and experiments to suggest that anti-PlGF treatment will not be effective for all tumors and why. Further, we show that PlGF blockage inhibits vessel abnormalization rather than density in certain tumors while enhancing VEGF-targeted inhibition in ocular disease. Our findings warrant further testing of anti-PlGF therapies.".
- aggregation authorList BK678599.
- aggregation endPage "190".
- aggregation issue "1".
- aggregation startPage "178".
- aggregation volume "141".
- aggregation aggregates 2937292.
- aggregation isDescribedBy 931075.
- aggregation similarTo j.cell.2010.02.039.
- aggregation similarTo LU-931075.