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- aggregation classification "A1".
- aggregation creator B416609.
- aggregation creator B416610.
- aggregation creator B416611.
- aggregation creator person.
- aggregation date "2009".
- aggregation hasFormat 931665.bibtex.
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- aggregation hasFormat 931665.doc.
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- aggregation isPartOf urn:issn:1535-3702.
- aggregation language "eng".
- aggregation publisher "SOC EXPERIMENTAL BIOLOGY MEDICINE".
- aggregation subject "Veterinary Sciences".
- aggregation title "In Vivo Expansion of the Mammary Stem/Progenitor Cell Population by Xanthosine Infusion".
- aggregation abstract "Mammary stem cells provide for growth and maintenance of the mammary gland and are therefore of considerable interest as determinants of productivity and efficiency of dairy animals and as targets of carcinogenesis in humans. Xanthosine treatment was previously shown to promote expansion of hepatic stem cells in vitro. The objective of this study was to determine if in vivo treatment with xanthosine can increase the mammary stem cell population. Xanthosine was infused into the right mammary glands of four female Holstein calves for 5 consecutive days. Immediately after each xanthosine treatment, calves were injected intravenously with 5-bromo-2-deoxyuridine (BrdU). Forty days after the final treatment, calves were euthanized and mammary tissue harvested. BrdU-label retaining epithelial cells (LREC) were detected immunohistochemically and quantified. Retention of BrdU was used as a marker for putative bovine mammary stem cells. Infusion of xanthosine into the bovine mammary gland significantly increased the number of LREC in treated glands compared to contralateral control glands (P < 0.05). LREC averaged 0.4% of epithelial cells in control glands and 0.8% in xanthosine-treated glands. The increase in LREC in xanthosine-treated glands was supported by a concomitant increase in telomerase activity (P < 0.01) and a correlation between LREC and telomerase (P < 0.05; r(2) = 0.7). Data indicate that in vivo treatment with xanthosine can be used to increase the number of mammary stem cells. This is the first demonstration of an in vivo treatment to increase the endogenous population of mammary stem cells, with utility for biomedical research and dairy management. Exp Biol Med 234:475-482, 2009".
- aggregation authorList BK736248.
- aggregation endPage "482".
- aggregation issue "4".
- aggregation startPage "475".
- aggregation volume "234".
- aggregation isDescribedBy 931665.
- aggregation similarTo 0811-RM-320.
- aggregation similarTo LU-931665.