Matches in UGent Biblio for { <https://biblio.ugent.be/publication/931722#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B375902.
- aggregation creator B375903.
- aggregation creator B375904.
- aggregation creator B375905.
- aggregation creator B375906.
- aggregation creator person.
- aggregation date "2007".
- aggregation format "application/pdf".
- aggregation hasFormat 931722.bibtex.
- aggregation hasFormat 931722.csv.
- aggregation hasFormat 931722.dc.
- aggregation hasFormat 931722.didl.
- aggregation hasFormat 931722.doc.
- aggregation hasFormat 931722.json.
- aggregation hasFormat 931722.mets.
- aggregation hasFormat 931722.mods.
- aggregation hasFormat 931722.rdf.
- aggregation hasFormat 931722.ris.
- aggregation hasFormat 931722.txt.
- aggregation hasFormat 931722.xls.
- aggregation hasFormat 931722.yaml.
- aggregation isPartOf urn:issn:0022-0302.
- aggregation language "eng".
- aggregation publisher "AMER DAIRY SCIENCE ASSOC".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Agriculture and Food Sciences".
- aggregation title "Regulation of gene expression in the bovine mammary gland by ovarian steroids".
- aggregation abstract "It is well established that estrogen is required for mammary epithelial cell proliferation and ductal development in the growing animal, and that lobuloalveolar development during gestation is dependent on progesterone. The effects of these steroid hormones on gene expression in the mammary gland are mediated primarily by their respective nuclear hormone receptors, which function as hormone-bound transcription factors. To gain insight into how estrogen and progesterone regulate mammary gland growth and function in cattle, we and others have characterized the expression patterns of their cognate nuclear hormone receptors in the bovine mammary gland throughout development, pregnancy, and lactation. This work has identified a lack of expression of estrogen receptor beta and a greater abundance of progesterone receptor during lactation in the bovine mammary gland, compared with the rodent gland. We speculate that interactions among the estrogen receptor isoforms that regulate progesterone receptor expression may contribute to these species differences. Further, demonstrated expression of substantial quantities of estrogen receptor within the prepubertal bovine mammary fat pad, along with coordinated insulin-like growth factor-I expression, suggests that this tissue may stimulate parenchymal growth via an estrogen-responsive paracrine mechanism. In addition, the recent availability of bovine genomic sequence information and microarray technologies has permitted the study of global gene expression in the mammary gland in response to the steroid environment. We have identified more than 100 estrogen-responsive genes, of which the majority are novel estrogen gene targets. Estrogen-induced changes in gene expression were consistent with increased mammary epithelial cell proliferation, increased extracellular matrix turnover in parenchyma, and increased extracellular matrix deposition in the fat pad. A comparison of estrogen-responsive genes in the mammary glands of humans, mice, and cattle suggests considerable variation among species, as well as potential differences in regulatory elements in common estrogen receptor gene targets. Continuing studies using advanced molecular techniques should assist in elucidating the complex regulation of mammary function at the transcript level.".
- aggregation authorList BK678736.
- aggregation endPage "E65".
- aggregation issue "suppl. 1".
- aggregation startPage "E55".
- aggregation volume "90".
- aggregation aggregates 942699.
- aggregation isDescribedBy 931722.
- aggregation similarTo jds.2006-466.
- aggregation similarTo LU-931722.