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- aggregation classification "A1".
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2010".
- aggregation format "application/pdf".
- aggregation hasFormat 936345.bibtex.
- aggregation hasFormat 936345.csv.
- aggregation hasFormat 936345.dc.
- aggregation hasFormat 936345.didl.
- aggregation hasFormat 936345.doc.
- aggregation hasFormat 936345.json.
- aggregation hasFormat 936345.mets.
- aggregation hasFormat 936345.mods.
- aggregation hasFormat 936345.rdf.
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- aggregation hasFormat 936345.txt.
- aggregation hasFormat 936345.xls.
- aggregation hasFormat 936345.yaml.
- aggregation isPartOf urn:issn:0014-4827.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Chibby interacts with NBPF1 and clusterin, two candidate tumor suppressors linked to neuroblastoma".
- aggregation abstract "The NBPF genes are members of a gene family that underwent a remarkable increase in their copy number during recent primate evolution. The NBPF proteins contain 5 to 40 copies of a domain known as the NBPF repeat or DUF1220. Very little is known about the function of these domains or about the NBPF proteins. We performed a yeast two-hybrid screening with the aminoterminal domain of NBPF11 and found that Chibby, a documented repressor of Wnt signaling, interacts with multiple NBPF proteins. More specifically, a coiled-coil region in the NBPF proteins interacts with the coiled-coil domain in the carboxyterminal region of Chibby. Nonetheless, this interaction did not influence the repressor function of Chibby in a TOPFLASH reporter assay. Using Chibby as bait in a new yeast two-hybrid screening, we identified clusterin as a binding protein. Chibby and clusterin were co-immunoprecipitated with NBPF1, suggesting the formation of a tri-molecular complex. Although we have not pinpointed the role of these mutual interactions, the possible formation of a macromolecular complex of three candidate tumor suppressor proteins, including the enigmatic NBPF1, points at important functional implications.".
- aggregation authorList BK888772.
- aggregation endPage "1233".
- aggregation issue "7".
- aggregation startPage "1225".
- aggregation volume "316".
- aggregation aggregates 2937294.
- aggregation aggregates 2937295.
- aggregation isDescribedBy 936345.
- aggregation similarTo j.yexcr.2010.01.019.
- aggregation similarTo LU-936345.