Matches in UGent Biblio for { <https://biblio.ugent.be/publication/977513#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B172719.
- aggregation creator B172720.
- aggregation creator B172721.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2009".
- aggregation format "application/pdf".
- aggregation hasFormat 977513.bibtex.
- aggregation hasFormat 977513.csv.
- aggregation hasFormat 977513.dc.
- aggregation hasFormat 977513.didl.
- aggregation hasFormat 977513.doc.
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- aggregation hasFormat 977513.txt.
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- aggregation hasFormat 977513.yaml.
- aggregation isPartOf urn:issn:0140-7783.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Veterinary Sciences".
- aggregation title "Influence of administration route on the biotransformation of amoxicillin in the pig".
- aggregation abstract "A comparison was made in the plasma concentration of the major metabolites of amoxicillin (AMO), i.e. amoxicilloic acid (AMA) and amoxicillin diketopiperazine-2',5'-dione (DIKETO) in portal and jugular venous plasma after oral (p.o.) and intravenous (i.v.) AMO administration to pigs, in order to study a possible presystemic degradation of AMO in the gastro-intestinal tract and liver. Almost identical plasma concentration-time curves were obtained for AMO and its metabolites in portal and jugular venous plasma, both after p.o. and i.v. AMO administration. Almost immediately after i.v. AMO administration, high AMA and DIKETO concentrations were measured in plasma, while after p.o. dosing, the metabolites appeared in plasma after almost complete absorption of AMO. No significant differences in pharmacokinetic parameters of AMO, AMA and DIKETO, derived from the concentration-time profiles in portal and jugular venous plasma were calculated, both after i.v. and p.o. AMO administration (P > 0.05). After p.o. administration, the half-life of elimination (t(1/2(el))) for AMA is at least two or three times the t(1/2(el)) of AMO (0.75 h for AMO vs. 2.69 h for AMA), indicating the slower clearance of the metabolite. It could be hypothesized that AMA is only eliminated by glomerular filtration, as its open beta-lactam structure might not be recognized by the transport carrier in the proximal tubule of the kidney. The results of the study indicate that AMO is not substantially metabolized presystemically in the gut and liver. Therefore, it may be assumed that the kidney may be the major organ for AMO biotransformation. Future in vivo and in vitro experiments should be performed to state this hypothesis.".
- aggregation authorList BK424395.
- aggregation endPage "248".
- aggregation issue "3".
- aggregation startPage "241".
- aggregation volume "32".
- aggregation aggregates 999724.
- aggregation isDescribedBy 977513.
- aggregation similarTo j.1365-2885.2008.01033.x.
- aggregation similarTo LU-977513.