Matches in UGent Biblio for { <https://biblio.ugent.be/publication/979570#aggregation> ?p ?o. }
Showing items 1 to 37 of
37
with 100 items per page.
- aggregation classification "A1".
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2011".
- aggregation format "application/pdf".
- aggregation hasFormat 979570.bibtex.
- aggregation hasFormat 979570.csv.
- aggregation hasFormat 979570.dc.
- aggregation hasFormat 979570.didl.
- aggregation hasFormat 979570.doc.
- aggregation hasFormat 979570.json.
- aggregation hasFormat 979570.mets.
- aggregation hasFormat 979570.mods.
- aggregation hasFormat 979570.rdf.
- aggregation hasFormat 979570.ris.
- aggregation hasFormat 979570.txt.
- aggregation hasFormat 979570.xls.
- aggregation hasFormat 979570.yaml.
- aggregation isPartOf urn:issn:0363-9045.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Development and evaluation of injection-moulded sustained-release tablets containing ethylcellulose and polyethylene oxide".
- aggregation abstract "It was the aim of the present study to develop sustained-release matrix tablets by means of injection moulding of ethylcellulose and polyethyleneoxide mixtures and to evaluate the influence of process temperature, matrix composition and viscosity grade of ethylcellulose and polyethyleneoxide on processability and drug release. Formulations consisting of metoprolol tartrate (MPT, concentration: 30%), ethylcellulose (EC) plasticized by dibutylsebacate and polyethyleneoxide (PEO) were extruded and consequently injection moulded into tablets. The influence of process temperature (120 and 140°C), matrix compostition, viscosity grade of ethylcellulose (4, 10, 20, 45 and 100mPa.s) and polyethyleneoxide (7.106, 1. 106 and 1.105 10 Mw) on processability and drug release was determined. Formulations consisting of 70% EC and 30% MPT showed incomplete drug release, whereas drug release was too fast for formulations without EC. Higher PEO concentrations increased drug release. Formulations containing 30% metoprolol, EC and different concentrations of PEO showed first-order release rates with limited burst release. Drug release from directed compressed tablets showed faster drug release rates compared to IM formulations. There was no clear relationship between the molecular weight of EC and drug release. The melting endotherm (113.9°C) of metoprolol tartrate observed in the DSC18 thermogram of the tablets indicated that a solid dispersion was formed which was confirmed by X-RD. X-ray tomography demonstrated a difference in pore structure between tablets processed at 120 and 140°C. It was concluded that injection moulding can be applied successfully to develop sustained release PEO/EC matrix tablets.".
- aggregation authorList BK494907.
- aggregation endPage "159".
- aggregation issue "2".
- aggregation startPage "149".
- aggregation volume "37".
- aggregation aggregates 1860935.
- aggregation isDescribedBy 979570.
- aggregation similarTo 03639045.2010.498426.
- aggregation similarTo LU-979570.