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- aggregation classification "A1".
- aggregation creator person.
- aggregation creator person.
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- aggregation date "2010".
- aggregation format "application/pdf".
- aggregation hasFormat 986003.bibtex.
- aggregation hasFormat 986003.csv.
- aggregation hasFormat 986003.dc.
- aggregation hasFormat 986003.didl.
- aggregation hasFormat 986003.doc.
- aggregation hasFormat 986003.json.
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- aggregation hasFormat 986003.yaml.
- aggregation isPartOf urn:issn:1615-9306.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "A bio-analytical hydrophilic interaction LC-MS/MS method for the simultaneous quantification of omeprazole and lansoprazole in human plasma in support of a pharmacokinetic omeprazole study in children".
- aggregation abstract "A hydrophilic interaction LC method with MS/MS was developed and validated for the simultaneous quantification of omeprazole and lansoprazole in human plasma. Chromatographic separation was achieved on a Betasil silica column using a high organic mobile phase (eluent A: ACN/formic acid 997.5:2.5 v/v; eluent B: water/formic acid 997.5:2.5 v/v) and gradient elution. The mass spectrometer was operated in the Multiple Reaction Monitoring mode. Prior to chromatography, liquid-liquid extraction with ethyl acetate was used and the organic layer was diluted with ACN, allowing direct injection on column. The method showed acceptable linearity, high precision (RSD%<10.5%), accuracy (88.9-109.3%) and selectivity in the two concentration ranges studied: 1.5-100 and 5-2000 ng/mL. The LOQ was established at 1.5 and 5 ng/mL for the two concentration ranges. Lack of variability in matrix effects was demonstrated and mean extraction recovery for omeprazole and lansoprazole was determined in the low (56.3-67.7%) and high (45.3-44.3%) concentration range, respectively. Additionally, plasma samples were found to be stable after three freeze-thaw cycles and for at least 15 h after extraction. This assay was successfully applied to a pharmacokinetic omeprazole study in children with cerebral palsy and mental retardation.".
- aggregation authorList BK674051.
- aggregation endPage "947".
- aggregation issue "6-7".
- aggregation startPage "939".
- aggregation volume "33".
- aggregation aggregates 1025962.
- aggregation isDescribedBy 986003.
- aggregation similarTo jssc.200900590.
- aggregation similarTo LU-986003.