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- 11β-hydroxysteroid_dehydrogenase_type_1 abstract "11β-hydroxysteroid dehydrogenase type 1, or 'cortisone reductase' is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system.In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors.It is inhibited by carbenoxolone, a drug typically used in the treatment of peptic ulcers.The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene.".
- 11β-hydroxysteroid_dehydrogenase_type_1 wikiPageID "5504724".
- 11β-hydroxysteroid_dehydrogenase_type_1 wikiPageRevisionID "593277516".
- 11β-hydroxysteroid_dehydrogenase_type_1 requireManualInspection "no".
- 11β-hydroxysteroid_dehydrogenase_type_1 updateCitations "yes".
- 11β-hydroxysteroid_dehydrogenase_type_1 updatePage "yes".
- 11β-hydroxysteroid_dehydrogenase_type_1 updateProteinBox "yes".
- 11β-hydroxysteroid_dehydrogenase_type_1 updateSummary "no".
- 11β-hydroxysteroid_dehydrogenase_type_1 subject Category:EC_1.1.1.
- 11β-hydroxysteroid_dehydrogenase_type_1 subject Category:Human_proteins.
- 11β-hydroxysteroid_dehydrogenase_type_1 type Biomolecule.
- 11β-hydroxysteroid_dehydrogenase_type_1 type Protein.
- 11β-hydroxysteroid_dehydrogenase_type_1 type BiologicalObject.
- 11β-hydroxysteroid_dehydrogenase_type_1 comment "11β-hydroxysteroid dehydrogenase type 1, or 'cortisone reductase' is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system.In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors.It is inhibited by carbenoxolone, a drug typically used in the treatment of peptic ulcers.The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. ".
- 11β-hydroxysteroid_dehydrogenase_type_1 label "11-бета-гидроксистероиддегидрогеназа 1-го типа".
- 11β-hydroxysteroid_dehydrogenase_type_1 label "11beta-Hydroxysteroid-Dehydrogenase 1".
- 11β-hydroxysteroid_dehydrogenase_type_1 label "11β-hydroxysteroid dehydrogenase type 1".
- 11β-hydroxysteroid_dehydrogenase_type_1 label "11β-hydroxystéroïde deshydrogénase (type 1)".
- 11β-hydroxysteroid_dehydrogenase_type_1 sameAs 11%CE%B2-hydroxysteroid_dehydrogenase_type_1.
- 11β-hydroxysteroid_dehydrogenase_type_1 sameAs 11beta-Hydroxysteroid-Dehydrogenase_1.
- 11β-hydroxysteroid_dehydrogenase_type_1 sameAs 11β-hydroxystéroïde_deshydrogénase_(type_1).
- 11β-hydroxysteroid_dehydrogenase_type_1 sameAs Q171604.
- 11β-hydroxysteroid_dehydrogenase_type_1 sameAs Q171604.
- 11β-hydroxysteroid_dehydrogenase_type_1 wasDerivedFrom 11β-hydroxysteroid_dehydrogenase_type_1?oldid=593277516.