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Matches in DBpedia 2014 for { <http://dbpedia.org/resource/2-isopropylmalate_synthase> ?p ?o. }

• 2-isopropylmalate_synthase abstract "In enzymology, a 2-isopropylmalate synthase (EC 2.3.3.13) is an enzyme that catalyzes the chemical reactionacetyl-CoA + 3-methyl-2-oxobutanoate + H2O (2S)-2-isopropylmalate + CoAThe three substrates of this enzyme are acetyl-CoA, 3-methyl-2-oxobutanoate, and H2O, and its products are (2S)-2-isopropylmalate and CoA.The enzyme belongs to the family of transferases, specifically those acyltransferases that convert acyl groups into alkyl groups on transfer. The systematic name of this enzyme class is acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming). Other names in common use include 3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase, (CoA-acetylating), alpha-isopropylmalate synthetase, alpha-isopropylmalate synthase, alpha-isopropylmalic synthetase, isopropylmalate synthase, and isopropylmalate synthetase. This enzyme participates in biosynthesis of L-leucine and pyruvate metabolism. Monovalent and divalent cation activation have been reported for enzymes from different sources. Mycobacterium tuberculosis α-isopropylmalate synthase requires a divalent metal ion, of which Mg2+ and Mn2+ give highest activity, and a monovalent cation, with K+ as the best activator. Zn2+ was shown to be an inhibitor, contrary to what was assumed from the structural data. In addition to the complex requirements for a divalent metal and further activation by K+, M. tuberculosis α-isopropylmalate synthase follows a random kinetic mechanism for catalysis.[citation needed] Another feature of the M. tuberculosis homolog is that L-leucine, the feedback inhibitor, inhibits the enzyme in a time-dependent fashion. This was the first demonstration of a feedback inhibitor that displays slow-onset inhibition.".
• 2-isopropylmalate_synthase ecNumber "2.3.3.13".
• 2-isopropylmalate_synthase wikiPageID "14540926".
• 2-isopropylmalate_synthase wikiPageRevisionID "545048631".
• 2-isopropylmalate_synthase casNumber "9030".
• 2-isopropylmalate_synthase ecNumber "2.3".
• 2-isopropylmalate_synthase goCode "3852".
• 2-isopropylmalate_synthase hasPhotoCollection 2-isopropylmalate_synthase.
• 2-isopropylmalate_synthase iubmbEcNumber "2".
• 2-isopropylmalate_synthase name "2".
• 2-isopropylmalate_synthase subject Category:EC_2.3.3.
• 2-isopropylmalate_synthase subject Category:Enzymes_of_known_structure.
• 2-isopropylmalate_synthase subject Category:Potassium_enzymes.
• 2-isopropylmalate_synthase type Biomolecule.
• 2-isopropylmalate_synthase type Enzyme.
• 2-isopropylmalate_synthase type BiologicalObject.
• 2-isopropylmalate_synthase comment "In enzymology, a 2-isopropylmalate synthase (EC 2.3.3.13) is an enzyme that catalyzes the chemical reactionacetyl-CoA + 3-methyl-2-oxobutanoate + H2O (2S)-2-isopropylmalate + CoAThe three substrates of this enzyme are acetyl-CoA, 3-methyl-2-oxobutanoate, and H2O, and its products are (2S)-2-isopropylmalate and CoA.The enzyme belongs to the family of transferases, specifically those acyltransferases that convert acyl groups into alkyl groups on transfer.".
• 2-isopropylmalate_synthase label "2-isopropilmalato sintasi".
• 2-isopropylmalate_synthase label "2-isopropylmalate synthase".
• 2-isopropylmalate_synthase sameAs 2-isopropilmalato_sintasi.
• 2-isopropylmalate_synthase sameAs m.03d72dk.
• 2-isopropylmalate_synthase sameAs Q3598014.
• 2-isopropylmalate_synthase sameAs Q3598014.
• 2-isopropylmalate_synthase sameAs 3179.
• 2-isopropylmalate_synthase wasDerivedFrom 2-isopropylmalate_synthase?oldid=545048631.
• 2-isopropylmalate_synthase isPrimaryTopicOf 2-isopropylmalate_synthase.
• 2-isopropylmalate_synthase name "2-isopropylmalate synthase".