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- 5-APDB abstract "5-(2-Aminopropyl)-2,3-dihydrobenzofuran (5-APDB, 3-Desoxy-MDA, EMA-4) is a putative entactogen drug of the phenethylamine and amphetamine classes. It is an analogue of MDA where the heterocyclic 3-position oxygen from the 3,4-methylenedioxy ring has been replaced by a methylene bridge. 6-APDB is an analogue of 5-APDB where the 4-position oxygen has been replaced by a methylene bridge instead. 5-APDB was developed by a team led by David E. Nichols at Purdue University as part of their research into non-neurotoxic analogues of MDMA.In animal studies, 5-APDB's effects generalize most closely to non-stimulant MDMA analogues such as MBDB and MMAI, while producing no substitution for LSD or amphetamine. In vitro studies show that 5-APDB acts as a highly selective serotonin releasing agent (SSRA), with IC50 values of 130 nM, 7,089 nM, and 3,238 nM for inhibiting the reuptake of serotonin, dopamine, and norepinephrine, respectively. In contrast, 6-APDB is more balanced on the three monoamine neurotransmitters and acts more similarly to MDA and MDMA. Anecdotal reports from human users suggest that 5-APDB produces mild empathy but with relatively little euphoria and is accompanied by sedation.[citation needed]Methoxy-substituted analogues of 5-APDB and 6-APDB have also been made and substituted for DOM in animal tests, although they were around 10x less potent than DOM.On June 10, 2013 5-APDB and a number of analogues were classified as Temporary Class Drugs in the UK following an ACMD recommendation. This means that sale and import of the named substances are criminal offences and are treated as for class B drugs.5-apdb has been used to stop bad comedown effects, panic attacks and withdrawals from methamphetamine, ice, a-pvp and mdpv producing a calmative sedative effect. Future use in treating patient with amphetamine problems in hospital emergency situations looks promising.Caution: when this compound (5-apdb) is mixed with hallucinogenic chemicals bad reactions including overdose may occur even at low doses.".
- 5-APDB atcPrefix "none".
- 5-APDB casNumber "152624-03-8".
- 5-APDB iupacName "1-(2,3-dihydro-1-benzofuran-5-yl)propan-2-amine".
- 5-APDB pubchem "192601".
- 5-APDB thumbnail 3-desoxy-MDA.svg?width=300.
- 5-APDB wikiPageID "20119063".
- 5-APDB wikiPageRevisionID "603819294".
- 5-APDB atcPrefix "none".
- 5-APDB c "11".
- 5-APDB casNumber "152624".
- 5-APDB chemspiderid "167143".
- 5-APDB h "15".
- 5-APDB hasPhotoCollection 5-APDB.
- 5-APDB inchi "1".
- 5-APDB inchikey "BZKLFXQUBIRXAK-UHFFFAOYAR".
- 5-APDB iupacName "1".
- 5-APDB legalStatus "Uncontrolled".
- 5-APDB molecularWeight "177.242".
- 5-APDB n "1".
- 5-APDB o "1".
- 5-APDB pregnancyCategory "?".
- 5-APDB pubchem "192601".
- 5-APDB routesOfAdministration "Oral".
- 5-APDB smiles "Cl.CCCc1cc2CCOc2cc1".
- 5-APDB stdinchi "1".
- 5-APDB stdinchikey "BZKLFXQUBIRXAK-UHFFFAOYSA-N".
- 5-APDB verifiedfields "changed".
- 5-APDB verifiedrevid "477223997".
- 5-APDB subject Category:Benzofurans.
- 5-APDB subject Category:Entactogens_and_empathogens.
- 5-APDB subject Category:Psychedelic_phenethylamines.
- 5-APDB type Drug.
- 5-APDB type FunctionalSubstance.
- 5-APDB comment "5-(2-Aminopropyl)-2,3-dihydrobenzofuran (5-APDB, 3-Desoxy-MDA, EMA-4) is a putative entactogen drug of the phenethylamine and amphetamine classes. It is an analogue of MDA where the heterocyclic 3-position oxygen from the 3,4-methylenedioxy ring has been replaced by a methylene bridge. 6-APDB is an analogue of 5-APDB where the 4-position oxygen has been replaced by a methylene bridge instead. 5-APDB was developed by a team led by David E.".
- 5-APDB label "5-APDB".
- 5-APDB sameAs m.04ygjmb.
- 5-APDB sameAs Q4639568.
- 5-APDB sameAs Q4639568.
- 5-APDB wasDerivedFrom 5-APDB?oldid=603819294.
- 5-APDB depiction 3-desoxy-MDA.svg.
- 5-APDB isPrimaryTopicOf 5-APDB.
