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- ADF-H_domain abstract "In molecular biology, ADF-H domain (actin-depolymerising factor homology domain) is an approximately 150 amino acid motif that is present in three phylogenetically distinct classes of eukaryotic actin-binding proteins.ADF/cofilins, which include ADF, cofilin, destrin, actophorin, coactosin, depactin and glia maturation factors (GMFs) beta and gamma. ADF/cofilins are small actin-binding proteins composed of a single ADF-H domain. They bind both actin-monomers and filaments and promote rapid filament turnover in cells by depolymerising/fragmenting actin filaments. ADF/cofilins bind ADP-actin with higher affinity than ATP-actin and inhibit the spontaneous nucleotide exchange on actin monomers Twinfilins, which are actin monomer-binding proteins that are composed of two ADF-H domainsAbp1/Drebrins, which are relatively large proteins composed of an N-terminal ADF-H domain followed by a variable region and a C-terminal SH3 domain. Abp1/Drebrins interact only with actin filaments and do not promote filament depolymerisation or fragmentation Although these proteins are biochemically distinct and play different roles in actin dynamics, they all appear to use the ADF-H domain for their interactions with actin.The ADF-H domain consists of a six-stranded mixed beta-sheet in which the four central strands (beta2-beta5) are anti-parallel and the two edge strands (beta1 and beta6) run parallel with the neighbouring strands. The sheet is surrounded by two alpha-helices on each side .".
- ADF-H_domain symbol "Cofilin_ADF".
- ADF-H_domain thumbnail PDB_1f7s_EBI.jpg?width=300.
- ADF-H_domain wikiPageID "32310962".
- ADF-H_domain wikiPageRevisionID "589138258".
- ADF-H_domain caption "crystal structure of adf1 from arabidopsis thaliana".
- ADF-H_domain cdd "cd00013".
- ADF-H_domain hasPhotoCollection ADF-H_domain.
- ADF-H_domain interpro "IPR002108".
- ADF-H_domain name "Cofilin_ADF".
- ADF-H_domain pfam "PF00241".
- ADF-H_domain pfamClan "CL0092".
- ADF-H_domain prosite "PDOC00297".
- ADF-H_domain scop "2".
- ADF-H_domain smart "ADF".
- ADF-H_domain symbol "Cofilin_ADF".
- ADF-H_domain subject Category:Protein_domains.
- ADF-H_domain type Abstraction100002137.
- ADF-H_domain type Attribute100024264.
- ADF-H_domain type Environment113934596.
- ADF-H_domain type ProteinDomains.
- ADF-H_domain type Situation113927383.
- ADF-H_domain type Sphere114514039.
- ADF-H_domain type State100024720.
- ADF-H_domain type Biomolecule.
- ADF-H_domain type Protein.
- ADF-H_domain type BiologicalObject.
- ADF-H_domain comment "In molecular biology, ADF-H domain (actin-depolymerising factor homology domain) is an approximately 150 amino acid motif that is present in three phylogenetically distinct classes of eukaryotic actin-binding proteins.ADF/cofilins, which include ADF, cofilin, destrin, actophorin, coactosin, depactin and glia maturation factors (GMFs) beta and gamma. ADF/cofilins are small actin-binding proteins composed of a single ADF-H domain.".
- ADF-H_domain label "ADF-H domain".
- ADF-H_domain sameAs m.0gy14y2.
- ADF-H_domain sameAs Q4651108.
- ADF-H_domain sameAs Q4651108.
- ADF-H_domain sameAs ADF-H_domain.
- ADF-H_domain wasDerivedFrom ADF-H_domain?oldid=589138258.
- ADF-H_domain depiction PDB_1f7s_EBI.jpg.
- ADF-H_domain isPrimaryTopicOf ADF-H_domain.
