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- ADP-ribose_diphosphatase abstract "ADP-ribose diphosphatase (EC 3.6.1.13) is an enzyme that catalyzes a hydrolysis reaction in which water nucleophilically attacks ADP-ribose to produce AMP and D-ribose 5-phosphate. Enzyme hydrolysis occurs by the breakage of a phosphoanhydride bond and is dependent on Mg2+ ions that are held in complex by the enzyme.The C-terminal domain of ADP-ribose diphosphatase contains the Nudix sequence, a highly conserved amino acid sequence that is found in over 450 putative proteins in about 90 different species. A part of this sequence known as the Nudix fold is the catalytic part of the sequence. It is a structurally conserved loop-helix-loop motif that creates a scaffold for metal binding and pyrophosphatase chemistry in the enzyme.ADP-ribose hydrolases in general act as protective agents against excessive intracellular accumulation of ADP-ribose, as high intracellular levels of ADP-ribose can be damaging to the cell. ADP-ribose diphosphatase, in particular, hydrolyzes ADP-ribose into AMP and D-ribose 5-phosphate, both of which are intermediates of central metabolic pathways and therefore are easily reused.Other common names for ADP-ribose diphosphatase include ADP-ribose pyrophosphatase and ADPRase. ADP-ribose is commonly referred to as ADPR.".
- ADP-ribose_diphosphatase ecNumber "3.6.1.13".
- ADP-ribose_diphosphatase thumbnail ADP_Ribose_Diphosphatase_(Pocket_shown_for_the_substrate).png?width=300.
- ADP-ribose_diphosphatase wikiPageExternalLink chimera.
- ADP-ribose_diphosphatase wikiPageExternalLink explore.do?structureId=1KHZ.
- ADP-ribose_diphosphatase wikiPageID "14337161".
- ADP-ribose_diphosphatase wikiPageRevisionID "534653670".
- ADP-ribose_diphosphatase casNumber "9024".
- ADP-ribose_diphosphatase ecNumber "3.6".
- ADP-ribose_diphosphatase goCode "47631".
- ADP-ribose_diphosphatase hasPhotoCollection ADP-ribose_diphosphatase.
- ADP-ribose_diphosphatase iubmbEcNumber "3".
- ADP-ribose_diphosphatase name "ADP-ribose diphosphatase".
- ADP-ribose_diphosphatase subject Category:EC_3.6.1.
- ADP-ribose_diphosphatase subject Category:Enzymes_of_known_structure.
- ADP-ribose_diphosphatase type Abstraction100002137.
- ADP-ribose_diphosphatase type Activator114723079.
- ADP-ribose_diphosphatase type Catalyst114723628.
- ADP-ribose_diphosphatase type Chemical114806838.
- ADP-ribose_diphosphatase type Compound114818238.
- ADP-ribose_diphosphatase type Enzyme114732946.
- ADP-ribose_diphosphatase type EnzymesOfKnownStructure.
- ADP-ribose_diphosphatase type Macromolecule114944888.
- ADP-ribose_diphosphatase type Material114580897.
- ADP-ribose_diphosphatase type Matter100020827.
- ADP-ribose_diphosphatase type Molecule114682133.
- ADP-ribose_diphosphatase type OrganicCompound114727670.
- ADP-ribose_diphosphatase type Part113809207.
- ADP-ribose_diphosphatase type PhysicalEntity100001930.
- ADP-ribose_diphosphatase type Protein114728724.
- ADP-ribose_diphosphatase type Relation100031921.
- ADP-ribose_diphosphatase type Substance100019613.
- ADP-ribose_diphosphatase type Thing100002452.
- ADP-ribose_diphosphatase type Unit109465459.
- ADP-ribose_diphosphatase type Biomolecule.
- ADP-ribose_diphosphatase type Enzyme.
- ADP-ribose_diphosphatase type BiologicalObject.
- ADP-ribose_diphosphatase comment "ADP-ribose diphosphatase (EC 3.6.1.13) is an enzyme that catalyzes a hydrolysis reaction in which water nucleophilically attacks ADP-ribose to produce AMP and D-ribose 5-phosphate.".
- ADP-ribose_diphosphatase label "ADP-ribose diphosphatase".
- ADP-ribose_diphosphatase sameAs m.03d0zcj.
- ADP-ribose_diphosphatase sameAs Q4651171.
- ADP-ribose_diphosphatase sameAs Q4651171.
- ADP-ribose_diphosphatase sameAs ADP-ribose_diphosphatase.
- ADP-ribose_diphosphatase wasDerivedFrom ADP-ribose_diphosphatase?oldid=534653670.
- ADP-ribose_diphosphatase depiction ADP_Ribose_Diphosphatase_(Pocket_shown_for_the_substrate).png.
- ADP-ribose_diphosphatase isPrimaryTopicOf ADP-ribose_diphosphatase.
- ADP-ribose_diphosphatase name "ADP-ribose diphosphatase".