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- ADP_ribosylation_factor abstract "ADP Ribosylation Factors (ARFs) are members of the ARF family of GTP-binding proteins of the Ras superfamily. ARF family proteins are ubiquitous in eukaryotic cells, and six highly conserved members of the family have been identified in mammalian cells. Although ARFs are soluble, they generally associate with membranes because of N-terminus myristoylation. They function as regulators of vesicular traffic and actin remodelling. The small ADP ribosylation factor (Arf) GTP-binding proteins are major regulators of vesicle biogenesis in intracellular traffic. They are the founding members of a growing family that includes Arl (Arf-like), Arp (Arf-related proteins) and the remotely related Sar (Secretion-associated and Ras-related) proteins. Arf proteins cycle between inactive GDP-bound and active GTP-bound forms that bind selectively to effectors. The classical structural GDP/GTP switch is characterised by conformational changes at the so-called switch 1 and switch 2 regions, which bind tightly to the gamma-phosphate of GTP but poorly or not at all to the GDP nucleotide. Structural studies of Arf1 and Arf6 have revealed that although these proteins feature the switch 1 and 2 conformational changes, they depart from other small GTP-binding proteins in that they use an additional, unique switch to propagate structural information from one side of the protein to the other.The GDP/GTP structural cycles of human Arf1 and Arf6 feature a unique conformational change that affects the beta2beta3 strands connecting switch 1 and switch 2 (interswitch) and also the amphipathic helical N-terminus. In GDP-bound Arf1 and Arf6, the interswitch is retracted and forms a pocket to which the N-terminal helix binds, the latter serving as a molecular hasp to maintain the inactive conformation. In the GTP-bound form of these proteins, the interswitch undergoes a two-residue register shift that pulls switch 1 and switch 2 up, restoring an active conformation that can bind GTP. In this conformation, the interswitch projects out of the protein and extrudes the N-terminal hasp by occluding its binding pocket.".
- ADP_ribosylation_factor symbol "Arf".
- ADP_ribosylation_factor thumbnail 1ksg_opm.gif?width=300.
- ADP_ribosylation_factor wikiPageID "4668380".
- ADP_ribosylation_factor wikiPageRevisionID "579999080".
- ADP_ribosylation_factor caption "Membrane-bound ADP ribosylation factor-like protein 2 , complex with phosphodiesterase delta Blue dots show hydrocarbon boundary of the lipid bilayer".
- ADP_ribosylation_factor cdd "cd00878".
- ADP_ribosylation_factor hasPhotoCollection ADP_ribosylation_factor.
- ADP_ribosylation_factor interpro "IPR006689".
- ADP_ribosylation_factor opmFamily "99".
- ADP_ribosylation_factor opmProtein "1".
- ADP_ribosylation_factor pfam "PF00025".
- ADP_ribosylation_factor prosite "PDOC01020".
- ADP_ribosylation_factor scop "1".
- ADP_ribosylation_factor smart "ARF".
- ADP_ribosylation_factor symbol "Arf".
- ADP_ribosylation_factor width "250".
- ADP_ribosylation_factor subject Category:Peripheral_membrane_proteins.
- ADP_ribosylation_factor subject Category:Protein_domains.
- ADP_ribosylation_factor type Abstraction100002137.
- ADP_ribosylation_factor type Attribute100024264.
- ADP_ribosylation_factor type Chemical114806838.
- ADP_ribosylation_factor type Compound114818238.
- ADP_ribosylation_factor type Environment113934596.
- ADP_ribosylation_factor type Macromolecule114944888.
- ADP_ribosylation_factor type Material114580897.
- ADP_ribosylation_factor type Matter100020827.
- ADP_ribosylation_factor type Molecule114682133.
- ADP_ribosylation_factor type OrganicCompound114727670.
- ADP_ribosylation_factor type Part113809207.
- ADP_ribosylation_factor type PeripheralMembraneProteins.
- ADP_ribosylation_factor type PhysicalEntity100001930.
- ADP_ribosylation_factor type Protein114728724.
- ADP_ribosylation_factor type ProteinDomains.
- ADP_ribosylation_factor type Relation100031921.
- ADP_ribosylation_factor type Situation113927383.
- ADP_ribosylation_factor type Sphere114514039.
- ADP_ribosylation_factor type State100024720.
- ADP_ribosylation_factor type Substance100019613.
- ADP_ribosylation_factor type Thing100002452.
- ADP_ribosylation_factor type Unit109465459.
- ADP_ribosylation_factor type Biomolecule.
- ADP_ribosylation_factor type Protein.
- ADP_ribosylation_factor type BiologicalObject.
- ADP_ribosylation_factor comment "ADP Ribosylation Factors (ARFs) are members of the ARF family of GTP-binding proteins of the Ras superfamily. ARF family proteins are ubiquitous in eukaryotic cells, and six highly conserved members of the family have been identified in mammalian cells. Although ARFs are soluble, they generally associate with membranes because of N-terminus myristoylation. They function as regulators of vesicular traffic and actin remodelling.".
- ADP_ribosylation_factor label "ADP ribosylation factor".
- ADP_ribosylation_factor label "Adenosyl-Ribosylierungs-Faktor".
- ADP_ribosylation_factor sameAs Adenosyl-Ribosylierungs-Faktor.
- ADP_ribosylation_factor sameAs m.0cgbsk.
- ADP_ribosylation_factor sameAs Q356188.
- ADP_ribosylation_factor sameAs Q356188.
- ADP_ribosylation_factor sameAs ADP_ribosylation_factor.
- ADP_ribosylation_factor wasDerivedFrom ADP_ribosylation_factor?oldid=579999080.
- ADP_ribosylation_factor depiction 1ksg_opm.gif.
- ADP_ribosylation_factor isPrimaryTopicOf ADP_ribosylation_factor.