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- AKAP13 abstract "A-kinase anchor protein 13 is an enzyme that in humans is encoded by the AKAP13 gene.The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins that have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in at least 3 transcript variants encoding different isoforms containing a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP-binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway and, in addition, function as protein kinase A-anchoring proteins.".
- AKAP13 entrezgene "11214".
- AKAP13 wikiPageID "14756455".
- AKAP13 wikiPageRevisionID "602991134".
- AKAP13 hasPhotoCollection AKAP13.
- AKAP13 requireManualInspection "no".
- AKAP13 summaryText "The A-kinase anchor proteins are a group of structurally diverse proteins that have the common function of binding to the regulatory subunit of protein kinase A and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in at least 3 transcript variants encoding different isoforms containing a dbl oncogene homology domain and a pleckstrin homology domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP-binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway and, in addition, function as protein kinase A-anchoring proteins.".
- AKAP13 updateCitations "yes".
- AKAP13 updatePage "yes".
- AKAP13 updateProteinBox "yes".
- AKAP13 updateSummary "yes".
- AKAP13 type Biomolecule.
- AKAP13 type Protein.
- AKAP13 type BiologicalObject.
- AKAP13 comment "A-kinase anchor protein 13 is an enzyme that in humans is encoded by the AKAP13 gene.The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins that have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family.".
- AKAP13 label "AKAP13".
- AKAP13 label "AKAP13".
- AKAP13 sameAs AKAP13.
- AKAP13 sameAs m.02lknm8.
- AKAP13 sameAs Q4652149.
- AKAP13 sameAs Q4652149.
- AKAP13 wasDerivedFrom AKAP13?oldid=602991134.
- AKAP13 isPrimaryTopicOf AKAP13.