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- AM-1220 abstract "AM-1220 is a drug that acts as a potent and moderately selective agonist for the cannabinoid receptor CB1, with around 19x selectivity for CB1 over the related CB2 receptor. It was originally invented in the early 1990s by a team led by Thomas D'Ambra at Sterling Winthrop, but has subsequently been researched by many others, most notably the team led by Alexandros Makriyannis at the University of Connecticut. The (piperidin-2-yl)methyl side chain of AM-1220 contains a stereocenter, so there are two enantiomers with quite different potency, the (R) enantiomer having a Ki of 0.27nM at CB1 while the (S) enantiomer has a much weaker Ki of 217nM. A number of related compounds are known with similar potent cannabinoid activity, with modifications such as substitution of the indole ring at the 2- or 6- positions, the naphthoyl ring substituted at the 4- position or replaced by substituted benzoyl rings or other groups, or the 1-(N-methylpiperidin-2-ylmethyl) group replaced by similar heterocyclic groups such as N-methylpyrrolidin-2-ylmethyl or N-methylmorpholin-3-ylmethyl. AM-1220 was first detected as an ingredient of synthetic cannabis smoking blends in 2010.".
- AM-1220 casNumber "137642-54-7".
- AM-1220 casSupplemental "(racemic)".
- AM-1220 casSupplemental "134959-64-1 ((R) enantiomer)".
- AM-1220 iupacName "(R)-(1-((1-methylpiperidin-2-yl)methyl)-1H-indol-3-yl)(naphthalen-1-yl)methanone".
- AM-1220 pubchem "9929889".
- AM-1220 thumbnail AM-1220_structure.png?width=300.
- AM-1220 wikiPageID "32279166".
- AM-1220 wikiPageRevisionID "544648977".
- AM-1220 c "26".
- AM-1220 casNumber "137642".
- AM-1220 casSupplemental "134959".
- AM-1220 chemspiderid "26231035".
- AM-1220 h "26".
- AM-1220 hasPhotoCollection AM-1220.
- AM-1220 iupacName "-methanone".
- AM-1220 legalAu "S9".
- AM-1220 legalStatus "banned under analog laws in some US states, Temporary Class Drug".
- AM-1220 molecularWeight "382.497".
- AM-1220 n "2".
- AM-1220 o "1".
- AM-1220 pubchem "9929889".
- AM-1220 smiles "O=CC3=CNC5=CC=CC=C53".
- AM-1220 stdinchi "1".
- AM-1220 stdinchikey "URKVBEKZCMUTQC-HXUWFJFHSA-N".
- AM-1220 verifiedrevid "454826769".
- AM-1220 width "200".
- AM-1220 subject Category:AM_cannabinoids.
- AM-1220 subject Category:Aminoalkylindoles.
- AM-1220 subject Category:Cannabinoids.
- AM-1220 subject Category:Designer_drugs.
- AM-1220 subject Category:Naphthoylindoles.
- AM-1220 subject Category:Piperidines.
- AM-1220 type Drug.
- AM-1220 type FunctionalSubstance.
- AM-1220 comment "AM-1220 is a drug that acts as a potent and moderately selective agonist for the cannabinoid receptor CB1, with around 19x selectivity for CB1 over the related CB2 receptor. It was originally invented in the early 1990s by a team led by Thomas D'Ambra at Sterling Winthrop, but has subsequently been researched by many others, most notably the team led by Alexandros Makriyannis at the University of Connecticut.".
- AM-1220 label "AM-1220".
- AM-1220 sameAs m.0gxzt_m.
- AM-1220 sameAs Q4652479.
- AM-1220 sameAs Q4652479.
- AM-1220 wasDerivedFrom AM-1220?oldid=544648977.
- AM-1220 depiction AM-1220_structure.png.
- AM-1220 isPrimaryTopicOf AM-1220.
