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- AM-4030 abstract "AM-4030 is an analgesic drug which is a cannabinoid receptor agonist. It is a derivative of HU-210 which has been substituted with a 6β-((E)-3-hydroxyprop-1-enyl) group. This adds a "southern" aliphatic hydroxyl group to the molecule as seen in the CP-series of nonclassical cannabinoid drugs, and so AM-4030 represents a hybrid structure between the classical and nonclassical cannabinoid families, with the 6-hydroxyalkyl chain rigidified with a double bond with defined stereochemistry. This gives AM-4030 a greater degree of selectivity, so while it is still a potent agonist at both CB1 and CB2, it is reasonably selective for CB1, with a Ki of 0.7nM at CB1 and 8.6nM at CB2, a selectivity of around 12x. Resolution of the enantiomers of AM-4030 yields an even more potent compound, although with less selectivity, with the (-) enantiomer AM-4030a having a Ki of 0.6nM at CB1 and 1.1nM at CB2.".
- AM-4030 iupacName "(6S,6aR,9R,10aR)-9-(hydroxymethyl)-6-[(E)-3-hydroxyprop-1-enyl]-6-methyl-3-(2-methyloctan-2-yl)-6a,7,8,9,10,10a-hexahydrobenzo[c]chromen-1-ol".
- AM-4030 pubchem "10550598".
- AM-4030 thumbnail AM-4030.png?width=300.
- AM-4030 wikiPageID "17361898".
- AM-4030 wikiPageRevisionID "512515874".
- AM-4030 c "27".
- AM-4030 chemspiderid "8725989".
- AM-4030 h "42".
- AM-4030 hasPhotoCollection AM-4030.
- AM-4030 inchi "1".
- AM-4030 inchikey "SYKOWCSKDYZBIL-BKTWVJDESA-N".
- AM-4030 iupacName "-9".
- AM-4030 molecularWeight "430.618".
- AM-4030 o "4".
- AM-4030 pubchem "10550598".
- AM-4030 smiles "OCC=CC3C1CCCCC1c2cccCCCCCCC".
- AM-4030 stdinchi "1".
- AM-4030 stdinchikey "SYKOWCSKDYZBIL-BKTWVJDESA-N".
- AM-4030 verifiedrevid "448104470".
- AM-4030 width "240".
- AM-4030 subject Category:AM_cannabinoids.
- AM-4030 subject Category:Alcohols.
- AM-4030 subject Category:Benzochromenes.
- AM-4030 subject Category:Cannabinoids.
- AM-4030 subject Category:Phenols.
- AM-4030 type Drug.
- AM-4030 type DrugProduct.
- AM-4030 type FunctionalSubstance.
- AM-4030 comment "AM-4030 is an analgesic drug which is a cannabinoid receptor agonist. It is a derivative of HU-210 which has been substituted with a 6β-((E)-3-hydroxyprop-1-enyl) group. This adds a "southern" aliphatic hydroxyl group to the molecule as seen in the CP-series of nonclassical cannabinoid drugs, and so AM-4030 represents a hybrid structure between the classical and nonclassical cannabinoid families, with the 6-hydroxyalkyl chain rigidified with a double bond with defined stereochemistry.".
- AM-4030 label "AM-4030".
- AM-4030 sameAs m.043qh41.
- AM-4030 sameAs Q4652492.
- AM-4030 sameAs Q4652492.
- AM-4030 wasDerivedFrom AM-4030?oldid=512515874.
- AM-4030 depiction AM-4030.png.
- AM-4030 isPrimaryTopicOf AM-4030.
